Research on Optimum Preparation Technology for β-Cyclodextrin Inclusion Compound of Volatile Oil from Rhizoma Chuanxiong by Orthogonal Design

WEI Xiao-liang; HU Jiu-mei; MAO Xia

doi:10.13422/j.cnki.syfjx.2011.05.041

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Research on Optimum Preparation Technology for β-Cyclodextrin Inclusion Compound of Volatile Oil from Rhizoma Chuanxiong by Orthogonal Design

更新时间：2024-09-23

- Research on Optimum Preparation Technology for β-Cyclodextrin Inclusion Compound of Volatile Oil from Rhizoma Chuanxiong by Orthogonal Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 46-49(2011)
- 作者机构：
  
  西南交通大学生命科学与工程学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.041
  CLC： R283
- Published：2011
- 稿件说明：
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[1]魏小亮,胡久梅,毛霞.正交设计法优选川芎挥发油的β-环糊精包合工艺[J].中国实验方剂学杂志,2011,17(05):46-49.

WEI Xiao-liang, HU Jiu-mei, MAO Xia. Research on Optimum Preparation Technology for β-Cyclodextrin Inclusion Compound of Volatile Oil from Rhizoma Chuanxiong by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 46-49.
[1]魏小亮,胡久梅,毛霞.正交设计法优选川芎挥发油的β-环糊精包合工艺[J].中国实验方剂学杂志,2011,17(05):46-49. DOI： 10.13422/j.cnki.syfjx.2011.05.041.

WEI Xiao-liang, HU Jiu-mei, MAO Xia. Research on Optimum Preparation Technology for β-Cyclodextrin Inclusion Compound of Volatile Oil from Rhizoma Chuanxiong by Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 46-49. DOI： 10.13422/j.cnki.syfjx.2011.05.041.

摘要

目的:优选β-环糊精（β-CD）包合川芎挥发油的最佳工艺。方法:采用L9（34）正交试验法

以β-CD与川芎挥发油的比例、包合温度、包合时间为考察因素

以挥发油包合率、包合物收得率及包合物含油率为综合评价指标

优选最佳的包合工艺

并对包合物进行验证。结果:川芎挥发油的β-CD最佳包合工艺为挥发油-β-CD（1∶8）

搅拌2 h

45℃下包合。结论:所建立的方法稳定可靠

挥发油包合率较高

适用于含川芎药材制剂的剂型改进。

Abstract

Objective:To optimize the preparation technology of β-cyclodextrin（β-CD） inclusion compound of volatile oil in Rhizoma Chuanxiong.Method:The study was carried out with L9（34） orthogonal design

using three indexes including the proportion of volatile oil to β-cyclodextrin

inclusion temperature and stirring time as the investigation factors

to evaluate the volatile oil utilization efficiency

inclusion yield and inclusion oil content compre-hensively

then choose the best preparation technology and validate the inclusion compound.Result:The optimum preparation condition for inclusion was established as:the ratio of volatile oil from Rhizoma Chuanxiong to β-CD was（1:8）;the temperature was at 45 ℃ and the stirring time was 2 h.Conclusion:The preparation procedure of including volatile oil was stable

reliable and was suitable for improving dosage form of Rhizoma Chuanxiong.

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Related Author

WEI Xiao-liang

HU Jiu-mei

MAO Xia

FU Liang

RAO Xiao-yong

HUANG Kai

XU Lan

GUI Chan

Related Institution

Jiangxi University of Traditional Chinese Medicine

National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine

Dongguan Hospital of Traditional Chinese Medicine

The Xinjiang Institute of Materia Medic

School of Pharmacy,Shihezi University

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