Study on Inhibitive Effect of Extracts from Cornus officinalis on α-Glucosidase

WANG Jun-xia; WU Xiao-hong; LI Chang-qin; CAO Nai-feng; KANG Wen-yi

doi:10.13422/j.cnki.syfjx.2011.05.047

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Study on Inhibitive Effect of Extracts from Cornus officinalis on α-Glucosidase

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- Study on Inhibitive Effect of Extracts from Cornus officinalis on α-Glucosidase
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 74-76(2011)
- 作者机构：
  
  河南大学中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.047
  CLC： R285
- Published：2011
- 稿件说明：
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[1]王俊霞,武晓红,李昌勤,曹乃锋,康文艺.山茱萸提取物对α-葡萄糖苷酶的抑制作用[J].中国实验方剂学杂志,2011,17(05):74-76.

WANG Jun-xia, WU Xiao-hong, LI Chang-qin, et al. Study on Inhibitive Effect of Extracts from Cornus officinalis on α-Glucosidase[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 74-76.
[1]王俊霞,武晓红,李昌勤,曹乃锋,康文艺.山茱萸提取物对α-葡萄糖苷酶的抑制作用[J].中国实验方剂学杂志,2011,17(05):74-76. DOI： 10.13422/j.cnki.syfjx.2011.05.047.

WANG Jun-xia, WU Xiao-hong, LI Chang-qin, et al. Study on Inhibitive Effect of Extracts from Cornus officinalis on α-Glucosidase[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 74-76. DOI： 10.13422/j.cnki.syfjx.2011.05.047.

摘要

目的:寻找山茱萸中具有抑制α-葡萄糖苷酶活性的成分。方法:用有机溶剂进行提取

在体外建立微量酶反应体系

以4-硝基苯-α-D-吡喃葡萄糖苷PNPG作为底物

阿卡波糖为阳性对照

检测山茱萸不同溶剂萃取物对α-葡萄糖苷酶抑制活性。结果:山茱萸石油醚萃取物[50%抑制浓度（IC50）=38.90 mg·L-1]、乙酸乙酯萃取物（IC50=2.40 mg·L-1）和正丁醇萃取物（IC50=4.26 mg·L-1）

远低于阳性对照阿卡波糖（IC50=1 081.27 mg·L-1）。结论:山茱萸各萃取物均具有很好的α-葡萄糖苷酶抑制活性

且乙酸乙酯萃取物的抑制活性最好。

Abstract

Objective:To search α-glucosidase inhibitors from Cornus officinalis.Method:All the extracts were extracted by organic solvent and the trace enzyme reaction system was constructed in vitro.Taking PNPG as substrate

acarbose as positive control

and inhibitive effect of extracts from C.officinalis on α-glucosidase was detec-ted.Result:The IC50 value of petroleum ether extracts（38.90 mg·L-1）

ethyl acetate extracts（2.40 mg·L-1） and n-butanol extracts（4.26 mg·L-1） were far lower than that of acarbose（1 081.27 mg·L-1） as positive control.Con-clusion:All the extracts of C.officinalis showed a better α-glucosidase inhibitory activity and ethyl acetate extracts showed the strongest inhibitory activity on α-glucosidase.

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