Studies on Anti-tumor Effect and Mechanism of Rhaponticum uniflorum in H22-bearing Mice

JIN Ai-hua1; XU Hui-xian2; LIU Wen-jing1; QUAN Ji-shu1; YIN Xue-zhe2

doi:10.13422/j.cnki.syfjx.2011.05.072

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Studies on Anti-tumor Effect and Mechanism of Rhaponticum uniflorum in H22-bearing Mice

更新时间：2024-09-23

- Studies on Anti-tumor Effect and Mechanism of Rhaponticum uniflorum in H22-bearing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 165-167(2011)
- 作者机构：
  
  1. 延边大学基础医学院
  2. 延边大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.072
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]金爱花,许惠仙,刘文静,全吉淑,尹学哲.祁州漏芦对H22小鼠肝癌皮下移植瘤的抑瘤作用及其机制初探[J].中国实验方剂学杂志,2011,17(05):165-167.

JIN Ai-hua1, XU Hui-xian2, LIU Wen-jing1, et al. Studies on Anti-tumor Effect and Mechanism of Rhaponticum uniflorum in H22-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 165-167.
[1]金爱花,许惠仙,刘文静,全吉淑,尹学哲.祁州漏芦对H22小鼠肝癌皮下移植瘤的抑瘤作用及其机制初探[J].中国实验方剂学杂志,2011,17(05):165-167. DOI： 10.13422/j.cnki.syfjx.2011.05.072.

JIN Ai-hua1, XU Hui-xian2, LIU Wen-jing1, et al. Studies on Anti-tumor Effect and Mechanism of Rhaponticum uniflorum in H22-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 165-167. DOI： 10.13422/j.cnki.syfjx.2011.05.072.

摘要

目的:探讨祁州漏芦水提物（RUWE）对小鼠H22移植瘤的生长抑制作用。方法:建立小鼠皮下H22移植瘤模型

将实验动物分为模型组、RUWE高、中、低剂量组和5-Fu组

RUWE按400

200

100 mg.kg-1.d-1剂量ig连续给药10 d

5-Fu组按25 mg.kg-1.d-1剂量隔日ip给药

处死动物

计算抑瘤率、胸腺指数和脾指数

并以ELISA法检测血清肿瘤坏死因子-α（TNF-α）和白介素-2（IL-2）

比色法检测血清总抗氧化活力（T-AOC）和丙二醛（MDA）含量。结果:与模型组相比

RUWE能显著减小移植瘤瘤重

提高抑瘤率

其RUWE高、中、低剂量组抑癌率分别为38.05%

34.98%

26.95%。同时

明显升高荷瘤小鼠的脾指数

增高血清IL-2和降低TNF-α

增高血清T-AOC和降低MDA水平。结论:RUWE对H22移植瘤具有明显的抑制作用

其作用可能与其增高机体免疫机能和抗氧化能力有关。

Abstract

Objective:To investigate the anti-tumor effect of Rhaponticum uniflorum water extract（RUWE）in H22-bearing mice.Method:The H22 transplanted mouse models were established and randomly divided into 5 groups:model

high

medium and low dose RUWE

and 5-Fu group.Animals were treated with ig 400

200

100 mg.kg-1.d-1 RUWE once daily for 10 days

and with ip 5-Fu 25 mg.kg-1.d-1 every other day for 3 times

then the tumor growth in-hibition ratios

spleen and thymus indexes were caluclated.The serum tumor necrosis factor-α（TNF-α）and interlekin-2（IL-2）was determined with ELISA method

the total antioxidant capacity（T-AOC）and malondialdehyde（MDA）con-tent were detected by colorimetric method.Result:The administration with 400

200

100 mg.kg-1.d-1 RUWE inhibi-ted the growth of transplanted tumor with the inhibitory ratios of 38.05%

34.98%

26.95%

respectively.In addi-tion

RUWE treatment elevated the spleen index

reduced the serum TNF-α level

increased the serum T-AOC and de-creased serum MDA level of H22-bearing mice.Conclusion:RUWE could exhibit an inhibitory effect on the growth of transplanted H22 tumor

probably via the improved immune function and antioxdative capability.

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Related Author

JIN Ai-hua

XU Hui-xian

LIU Wen-jing

QUAN Ji-shu

YIN Xue-zhe

CHEN Lanpin

TAN Feng

WEI Xiaoman

Related Institution

The Affiliated Hospital of Nanjing University of Chinese Medicine

Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine for Tumor Prevention and Treatment

The First School of Clinical Medicine of Nanjing University of Chinese Medicine

School of Clinical Medicine of Nanjing University of Chinese Medicine

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

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