ZHANG Rui1, SONG Jian-ping1, LI Rui-qin1, et al. Effect of Jingui Shenqi Pill on Expression of Platelet-derived Growth Factor-BB of Lung in Rats with Pulmonary Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 173-176.
ZHANG Rui1, SONG Jian-ping1, LI Rui-qin1, et al. Effect of Jingui Shenqi Pill on Expression of Platelet-derived Growth Factor-BB of Lung in Rats with Pulmonary Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 173-176. DOI: 10.13422/j.cnki.syfjx.2011.05.073.
Effect of Jingui Shenqi Pill on Expression of Platelet-derived Growth Factor-BB of Lung in Rats with Pulmonary Fibrosis
Objective:To investigate the effect and mechanism of Jingui Shenqi Pill(JGSQ)on pulmonary fibrosis.Method:Pulmonary fibrosis was induced by bleomycinA5 in SD rats.Rats in drug group were killed after being treated by taking JGSQ daily for 28 days.The lungs of all rats were harvested for histopathological studies.The contents of platelet-derived growth factor-BB(PDGF-BB)in lungs were measured and compared.Result:The degree of the alveolitis and pulmonary fibrosis
the contents of PDGF-BB in lungs increased significantly in the model group as compared with that in the normal group and the JGSQ treated group(P < 0.05).Conclusion:The contents of PDGF-BB in lungs from the rats with pulmonary fibrosis were significantly higher than that of the normal rats
JGSQ could significantly alleviate the increase and the degree of alveolitis and pulmonary fibrosis.
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Related Author
ZHANG Rui
SONG Jian-ping
LI Rui-qin
LI Wei
LIU Fang-zhou
WANG Gang
YUE Rensong
YANG Qiyue
Related Institution
Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Zigong First People's Hospital
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of TCM
College of Food and Biological Engineering, Chengdu University
Key Laboratory of Biological Evaluation of Traditional Chinese Medicine(TCM) Quality of National Administration of TCM,Sichuan Academy of Chinese Medicine Sciences