Experimental Study on Decomposing Prescription of Sijunzi Decoction to Resist Exercise-induced Fatigue in Mice

ZHANG Cai1; CAO Hai-tao2

doi:10.13422/j.cnki.syfjx.2011.05.077

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Experimental Study on Decomposing Prescription of Sijunzi Decoction to Resist Exercise-induced Fatigue in Mice

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- Experimental Study on Decomposing Prescription of Sijunzi Decoction to Resist Exercise-induced Fatigue in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 187-189(2011)
- 作者机构：
  
  1. 上海中医药大学体育部中心运动医学教研室
  2. 2. 德克萨斯州中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.077
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]张彩,曹海涛.四君子汤抗小鼠运动性疲劳拆方研究[J].中国实验方剂学杂志,2011,17(05):187-189.

ZHANG Cai1, CAO Hai-tao2. Experimental Study on Decomposing Prescription of Sijunzi Decoction to Resist Exercise-induced Fatigue in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 187-189.
[1]张彩,曹海涛.四君子汤抗小鼠运动性疲劳拆方研究[J].中国实验方剂学杂志,2011,17(05):187-189. DOI： 10.13422/j.cnki.syfjx.2011.05.077.

ZHANG Cai1, CAO Hai-tao2. Experimental Study on Decomposing Prescription of Sijunzi Decoction to Resist Exercise-induced Fatigue in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 187-189. DOI： 10.13422/j.cnki.syfjx.2011.05.077.

摘要

目的:对四君子汤进行拆方研究

筛选出抗小鼠运动性疲劳的有效中药组合。方法:将64只小鼠随机分为四君子游泳组、四君子非游泳组、党参组和白术茯苓组

每组16只

采用逐渐递增的游泳训练模式建立疲劳模型

4周后进行力竭游泳后处死

观察小鼠体重、乳酸（LA）、肌酸激酶（CK）、肝糖原（HG）、尿素氮（BUN）、乳酸脱氢酶（LDH）等指标的变化。结果:各组小鼠体重

LDH比较无显著性差异。四君子游泳组CK明显高于其他组（P<0.05）。党参组的BUN明显低于其他组（P<0.05）。结论:党参可以通过清除BUN

四君子整方通过降低CK达到缓解运动性疲劳的作用。

Abstract

Objective:The purpose of this study was to screen the effective herbal combination to resist ex-ercise-induced fatigue by decomposing Sijunzi decoction.Method:The total of 64 mice were randomly divided into four groups:Sijunzi decoction swimming group

Sijunzi decoction（no swimming）group

Dangshen group

and Baizhu-fuling group.There were 16 mice in each group.Animal model of exercise-induced fatigue was created by gradually increasing swimming time.Mice were killed four weeks later after exhausted swimming.Chang of indices including body weight of the mice

lactic acid（LD）

creatine kinase（CK）

liver glycogen（HG）

blood urea nitrogen（BUN）

lactate dehydrogenase（LDH） were tested.Result:There was no statistically significance of body weight

BUN and LDH between each group.CK level of Sijunzi decoction swimming group was significantly lower than other groups（P < 0.05）.BUN level of Dangshen decoction was significantly lower than other groups（P < 0.05）.Conclu-sion:Danshen resists exercise-induced fatigue by reducing BUN and Sijunzi decoction resists exercise-induced fa-tigue by reducing CK.

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