Effect of Zedoary Oil on X-linked Inhibitor of Apoptosis Protein mRNA Expression in Human Nasopharyngeal Carcinoma Cell

XIA Chun-bo1; JIANG Chang-wen1; QIN Xiao-yun2; ZHENG Chu3; MEN Nan1; SUN Jing-xia1

doi:10.13422/j.cnki.syfjx.2011.05.085

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Effect of Zedoary Oil on X-linked Inhibitor of Apoptosis Protein mRNA Expression in Human Nasopharyngeal Carcinoma Cell

更新时间：2024-09-23

- Effect of Zedoary Oil on X-linked Inhibitor of Apoptosis Protein mRNA Expression in Human Nasopharyngeal Carcinoma Cell
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 5, Pages: 204-206(2011)
- 作者机构：
  
  1. 桂林医学院人体解剖学教研室
  2. 柳州医学高等专科学校
  3. 桂林医学院附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.05.085
  CLC： R739.63
- Published：2011
- 稿件说明：
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[1]夏春波,蒋常文,秦小云,郑楚,门楠,孙婧霞.莪术油对鼻咽癌细胞X-连锁凋亡抑制蛋白mRNA表达的影响[J].中国实验方剂学杂志,2011,17(05):204-206.

XIA Chun-bo1, JIANG Chang-wen1, QIN Xiao-yun2, et al. Effect of Zedoary Oil on X-linked Inhibitor of Apoptosis Protein mRNA Expression in Human Nasopharyngeal Carcinoma Cell[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 204-206.
[1]夏春波,蒋常文,秦小云,郑楚,门楠,孙婧霞.莪术油对鼻咽癌细胞X-连锁凋亡抑制蛋白mRNA表达的影响[J].中国实验方剂学杂志,2011,17(05):204-206. DOI： 10.13422/j.cnki.syfjx.2011.05.085.

XIA Chun-bo1, JIANG Chang-wen1, QIN Xiao-yun2, et al. Effect of Zedoary Oil on X-linked Inhibitor of Apoptosis Protein mRNA Expression in Human Nasopharyngeal Carcinoma Cell[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 204-206. DOI： 10.13422/j.cnki.syfjx.2011.05.085.

摘要

目的:研究莪术油对鼻咽癌细胞X-连锁凋亡抑制蛋白（X-linked inhibitor of apoptosis protein

XIAP）mRNA表达的影响及其作用机制。方法:体外培养鼻咽癌CNE-2细胞

MTT（噻唑蓝）法观察莪术油（400

300

200

100 mg·L-1）对CNE-2细胞的抑制作用

RT-PCR法检测莪术油对CNE-2细胞XIAPmRNA表达的影响。结果:MTT法结果显示

莪术油对CNE-2细胞的抑制率呈时间-剂量依赖性（P<0.01）。与对照组相比

莪术油139.41 mg·L-1组XIAPmRNA表达水平明显降低（P<0.01）。结论:莪术油能明显抑制鼻咽癌CNE-2细胞生长

其机制可能是通过抑制XIAP基因的表达。

Abstract

Objective:To investigate the effect of zedoary oil on XIAPmRNA expression in nasopharyngeal carcinoma cell and its mechanism.Method:Using the MTT assay to display the sensitivity to the drug

the inhibition of zedoary oil（400

300

200

100 mg·L-1） to nasopharyngeal carcinoma cell（CNE-2）in vitro was observed.XIAP mRNA expression was tested by RT-PCR assay in CNE-2 cell.Result:The inhibition rate of zedoary oil to CNE-2 indicated both dose-dependent and time-dependent antiproliferative effect by MTT assay（P < 0.01）.Compared with control group

the expression level of the XIAPmRNA was decreased obviously in the experiment group（zedoary oil 139.41 mg·L-1）（P < 0.01）.Conclusion:The proliferation of CNE-2 cell was inhibited obviously by zedoary oil and the mechanism may be related to inbhibition of expression of XIAP.

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