Objective:To evaluate the efficacy and safety of Ephedra decoction of original dosage of treatise on febrile disease in the treatment of influenza with cold syndrome.Method: A randomized

positive drug-led trial was conducted on patients（aged 18 to 65 years）with cold syndrome in influenza

which presented influenza symptoms and elevated body temperature（38.0 ℃ or higher） within 48 hours.These patients were randomly divided into 3 groups:group A（32 patients

Ephedra decoction of original dosage

oral decoction 3 times a day

for 3 days）

group B（31 patients

Ephedra decoction of conventional dosage recommended by the textbook of the current Chinese medicine colleges and universities

oral decoction 3 times a day

for 3 days）

group C（30 patients

compound dextromethorphan hydrobromide granules

1-2 granules once

3 times a day

for 3 days）.Result: ninty three patients with cold syndrome of influenza were defined as effective analysis cases（32 cases in group A

31 cases in group B and 30 cases in group C.①The total significant efficiency rate of 24 h temperature effect test in group A was 93.75%（30/32）

which was significantly higher than that in group B（67.74%

21/31）and in group C（36.67%

11/30）（P<α′=0.017）.②The effective rate of TCM symptoms test in group A was（90.63%

29/32）

which was significantly higher than that in group B（61.29%

19/31））and in group C（30.00%

9/30）

there was a significant difference between group A

group B and group C（P<0.017）.③The effect of remission fever and symptoms:The course of fever and symptoms in group A was（23.91±12.87） h and（38.45±20.53） h

which was significantly shorter than that in group B（35.78±16） h

（51.34±29.71） h and that in group C（85.45±22.16） h

（106.34±35.45）h

through binary comparison of the 3 groups（P<0.05）.④The ratio of complications incidence and antibiotic utilization:3.13%（1/32）and 3.13%（1/32）in group A

which was significantly lower than that in group C（30.00%

9/30）

30.00%（9/30）（P<0.017）.For safety analysis

adverse reaction was found in neither group A nor group B

except for 1 case of somnolence

1 case of dizziness

1 case of stomach discomfort in group C.Conclusion: Ephedra decoction of original dosage can effectively shorten the course of influenza

alleviate influenza symptoms

shorten fever time and reduce the incidence of influenza complications.The clinical curative effect was significantly better than Ephedra decoction of conventional dosage or dextromethorphan hydrobromide granules.Ephedra decoction of original dosage is effective and quite safe in treating early influenza.