ZHENG Li-qing1, LIU Jian-hua2, HAN Wei-xuan1, et al. Preparation of Osthol Microcapsules and Observation of its Release Rate in vitro[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 8-11.
ZHENG Li-qing1, LIU Jian-hua2, HAN Wei-xuan1, et al. Preparation of Osthol Microcapsules and Observation of its Release Rate in vitro[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 8-11. DOI: 10.13422/j.cnki.syfjx.2011.13.021.
Preparation of Osthol Microcapsules and Observation of its Release Rate in vitro
摘要
目的:制备蛇床子素缓释微囊并考察其体外释放规律。方法:以明胶、阿拉伯胶为囊材
采用复凝聚法制备微囊
采用紫外分光光度法测含量
均匀设计优化制备工艺。分别以150 mL人工胃液与磷酸盐缓冲液(pH 6.8)为溶出介质
温度(37±0.5)℃
转速100 r·min-1
测定其体外释放度。结果:最佳制备工艺为囊心囊材质量比1∶1.5
温度60℃
戊二醛用量0.8∶120(戊二醛用量/系统体积)
制备的微囊圆整光滑
粒径均匀
平均粒径(51.6±4)μm
包封率85.0%
载药量47.2%
体外缓释时间为6 h
其释药特征符合一级动力学过程。结论:蛇床子素微囊制备工艺简单
成囊性和重复性好
微囊具有明显的缓释效果。
Abstract
Objective:To prepare osthol microcapsules and study its release rate in vitro.Method: Osthol microcapsules were prepared by complex coacervation using gelatin-acacia and uniform design.Osthol content was determined by UV.150 mL artificial gastric and PBS(pH 6.8) were used as releasing media
the temperature was(37±0.5) ℃ and the rate of rotation was 100 r·min-1.Result: The optimized conditions were: the ratio of osthol and coating material of 1∶1.5
temperature of 60 ℃ and a hardening agent of 0.8 per 120 of coacervation system.The microcapsules were round under sphere.The average microcapsules diameters were(51.6±4)μm.And the content of osthol was 47.2% with coating ratio of 85.0%.The microcapsules could be released for 6 h in vitro and its releasing curve fit first-order dynamic equations.Conclusion: The preparation method is simple and osthol microcapsules have obvious sustained-release effect.
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Related Author
ZHENG Li-qing
LIU Jian-hua
HAN Wei-xuan
ZHANG Dan-shen
XUE Gui-ping
CUI Ming-yu
WANG Yan
SUN Zhi-wei
Related Institution
School of Nursing, Chengdu University of Traditional Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine
School of Mathematics,Southwest Jiaotong University
College of Integrated Traditional Chinese and Western Medicine,Medical School, Hunan University of Chinese Medicine