Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index

ZHENG Lin; HUANG Yong; LAN Yan-yu; WANG Yong-lin; CHI Ming-yan

doi:10.13422/j.cnki.syfjx.2011.13.026

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Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index

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- Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 26-29(2011)
- 作者机构：
  
  贵阳医学院药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.026
  CLC： R283.6
- Published：2011
- 稿件说明：
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[1]郑林,黄勇,兰燕宇,王永林,迟明艳.化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺[J].中国实验方剂学杂志,2011,17(13):26-29.

ZHENG Lin, HUANG Yong, LAN Yan-yu, et al. Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 26-29.
[1]郑林,黄勇,兰燕宇,王永林,迟明艳.化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺[J].中国实验方剂学杂志,2011,17(13):26-29. DOI： 10.13422/j.cnki.syfjx.2011.13.026.

ZHENG Lin, HUANG Yong, LAN Yan-yu, et al. Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 26-29. DOI： 10.13422/j.cnki.syfjx.2011.13.026.

摘要

目的:用化学指标结合药效学指标评价紫金透骨喷雾剂不同提取工艺的科学性及合理性

优选紫金透骨喷雾剂的最佳提取工艺。方法:分别采用6种提取工艺制备紫金透骨喷雾剂样品

用HPLC测定白花丹醌、水杨酸甲酯和militarine含量

并观察6种工艺样品的抗急性软组织损伤作用和抗炎作用。结果:乙醇低温提取（渗漉、浸渍）样品的效果优于乙醇回流提取和水煎煮提取

且渗漉提取样品优于浸渍提取。结论:紫金透骨喷雾剂以乙醇渗漉提取工艺的综合指标优于其他工艺。

Abstract

Objective:To use chemical index and pharmacodynamics index to optimize the extraction technology of Zijintougu sprays.Method: six samples of Zijintougu sprays were prepared by different extraction technology.The content of plumbagin

methyl salicylate and militarine was determined in Zijintougu sprays by HPLC.The resistance to acute soft tissue injury and anti-inflammtory effect of 6 technological samples was observed.Result: Integrating the results of chemical index and pharmacodynamics index

the samples with ethanol low temperature extraction（percolation extraction

macerate extraction） were superior to the samples with ethanol refluxing extraction and water boiling extraction

and the sample with percolation extraction was superior to the sample with macerate extraction.Conclusion: The comprehensive indexes of Zijintougu sprays with ethanol percolation extraction were superior to that of other extraction technology.

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