Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers

JIANG Yan1; ZHANG Wei1; LIN Xiu-yan1; LIU Jing1; XIN Hui1; CHEN Ying1; ZHANG Zhuo-bo2

doi:10.13422/j.cnki.syfjx.2011.13.051

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Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers

更新时间：2024-09-23

- Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 110-112(2011)
- 作者机构：
  
  1. 齐齐哈尔医学院附属第三医院
  2. 哈尔滨医科大学第四附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.051
  CLC： R285.6
- Published：2011
- 稿件说明：
移动端阅览
[1]姜岩,张伟,林秀艳,刘晶,信慧,陈迎,张卓伯.灯盏花素片在健康人体内的药代动力学研究[J].中国实验方剂学杂志,2011,17(13):110-112.

JIANG Yan1, ZHANG Wei1, LIN Xiu-yan1, et al. Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 110-112.
[1]姜岩,张伟,林秀艳,刘晶,信慧,陈迎,张卓伯.灯盏花素片在健康人体内的药代动力学研究[J].中国实验方剂学杂志,2011,17(13):110-112. DOI： 10.13422/j.cnki.syfjx.2011.13.051.

JIANG Yan1, ZHANG Wei1, LIN Xiu-yan1, et al. Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 110-112. DOI： 10.13422/j.cnki.syfjx.2011.13.051.

摘要

目的:建立测定人血浆中灯盏花素浓度的高效液相色谱法。方法:色谱柱Kromasil C18（4.6 mm×250 mm

5μm）;流动相甲醇-水-冰醋酸（30∶70∶1）检测波长:335 nm;灯盏乙素作为内标

用HPLC测定人血浆中灯盏花素浓度。结果:灯盏花素线性范围为0.30～18.0 mg·L-1

回归方程Y=0.008 7C-0.001 56（r=0.999 6）;回收率>80%

日内和日间RSD均<10%。结论:方法简便、快速、准确

适用于灯盏花素药代动力学研究及血药浓度监测。

Abstract

Objective:To establish a high performance liquid chromatographic method for determination the concentration of breviscapine in plasma of healthy volunteers.Method:The assay was conducted on the Kromasil C18（250 mm×4.6 mm

5 μm）columnn with methanol-water-glacial acetic acid（30∶70∶1）as the mobile phase.The detection wave length was set at 335 nm

and scutellarin was taken as the internal standard.Result:The linearity range was 0.30-18.0 mg·L-1 with a regressive equation of Y=0.008 7 C-0.001 56（r=0.999 6）.The recovery was above 80%

with both intra-day RSD and inter-day RSD below 10%.Conclusion:The method was shown to be convenient

rapid

accurate

and suitable for the pharmacokinetic study of breviscapine and monitoring its concentration in clinical application.

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Related Author

JIANG Yan

ZHANG Wei

LIN Xiu-yan

LIU Jing

XIN Hui

CHEN Ying

ZHANG Zhuo-bo

Liu Hong

Related Institution

Research Institute of Tianjin University of Traditional Chinese Medicine,Key Laboratory of Traditional Chinese Medical Formulation in Ministry of Education

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

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