Effects of Zhaqi Jiangtang Decoction on Blood Glucose and Oxidative Stress in Diabetic Rats

LI Jin1; HUANG Xue-kuan1; REN Ling-yan2; SHEN Qing1

doi:10.13422/j.cnki.syfjx.2011.13.055

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Effects of Zhaqi Jiangtang Decoction on Blood Glucose and Oxidative Stress in Diabetic Rats

更新时间：2024-09-23

- Effects of Zhaqi Jiangtang Decoction on Blood Glucose and Oxidative Stress in Diabetic Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 124-126(2011)
- 作者机构：
  
  1. 重庆医科大学中医药学院
  2. 重庆科技学院化学化工学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.055
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]李进,黄学宽,任凌燕,沈清.楂芪降糖汤对实验性糖尿病大鼠血糖及氧化应激的影响[J].中国实验方剂学杂志,2011,17(13):124-126.

LI Jin1, HUANG Xue-kuan1, REN Ling-yan2, et al. Effects of Zhaqi Jiangtang Decoction on Blood Glucose and Oxidative Stress in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 124-126.
[1]李进,黄学宽,任凌燕,沈清.楂芪降糖汤对实验性糖尿病大鼠血糖及氧化应激的影响[J].中国实验方剂学杂志,2011,17(13):124-126. DOI： 10.13422/j.cnki.syfjx.2011.13.055.

LI Jin1, HUANG Xue-kuan1, REN Ling-yan2, et al. Effects of Zhaqi Jiangtang Decoction on Blood Glucose and Oxidative Stress in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 124-126. DOI： 10.13422/j.cnki.syfjx.2011.13.055.

摘要

目的:研究楂芪降糖汤对糖尿病大鼠血糖及氧化应激的影响。方法:链脲佐菌素（STZ）腹腔注射诱导糖尿病大鼠模型

造模成功后分别以楂芪降糖汤（5.5

22 g·kg-1）、优降糖（5×10-3 g·kg-1）ig。治疗4周后

进行空腹血糖及抗氧化指标的检测。结果:与正常对照组比较

模型组大鼠空腹血糖（FBG）、血清丙二醛（MDA）含量明显升高

血清过氧化氢酶（CAT）、超氧化物歧化酶（SOD）活性则明显降低（P<0.05）

而楂芪降糖汤可以降低糖尿病大鼠FBG及MDA的含量

还可提高其血清CAT

SOD的活性（P<0.05）。结论:楂芪降糖汤具有明显降糖作用

其作用机制可能与降低氧化应激水平有关。

Abstract

Objective:To investigate the effects of Zhaqi Jiangtang Decoction on blood glucose and oxidative stress in diabetic rats.Method:The mode1 rats of diabetes were made by injection STZ into the abdominal cavity.After the model formed

the rats with diabetes were treated with Zhaqi Jiangtang Decoction

Youjiangtang through gastric feeding.The treatment lasted for 4 weeks

the influence on fasting blood glucose（FBG）

superoxide dismutase（SOD）

catalase（CAT）maleicdialdehyde（MDA）for treated rats with diabetes was observed.Result: The levels of FBG and SOD were increased significantly

and the levels of CAT and SOD reduced significantly in the blood serum of the model rats compared to the normal group（P<0.05）;Zhaqi Jiangtang Decoction could not only reduce the 1evers of FBG and MDA

but also rise the 1evels of CAT and SOD in the model rats（P<0.05）.Conclusion:Zhaqi Jiangtang Decoction has obvious effect to reduce the blood glucose and its mechanism may be related to inhibition of oxidative stress in diabetic rats.

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REN Ling-yan

SHEN Qing

LIU Yong-sheng

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Related Institution

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Beijing University of Chinese Medicine

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Hebei University of Chinese Medicine

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