Effect of Dachengqi Decoction on Cytokines Tumor Necrosis Inflammatory Cytokines in Rats with Endotoxaemia

MA Chao-ying1; ZHOU Juan2; LI Hai-lin2; GENG Yun1; TANG Jing-wen1; PENG Chun-rong1; TU Xian-qin1; XU Yin-sheng1

doi:10.13422/j.cnki.syfjx.2011.13.057

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Effect of Dachengqi Decoction on Cytokines Tumor Necrosis Inflammatory Cytokines in Rats with Endotoxaemia

更新时间：2024-09-23

- Effect of Dachengqi Decoction on Cytokines Tumor Necrosis Inflammatory Cytokines in Rats with Endotoxaemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 130-133(2011)
- 作者机构：
  
  1. 西南交通大学生命科学与工程学院
  2. 青海省中医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.057
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]马超英,周鹃,李海霖,耿耘,唐静雯,彭春荣,涂显琴,徐寅生.大承气汤对内毒素血症大鼠炎性细胞因子的影响[J].中国实验方剂学杂志,2011,17(13):130-133.

MA Chao-ying1, ZHOU Juan2, LI Hai-lin2, et al. Effect of Dachengqi Decoction on Cytokines Tumor Necrosis Inflammatory Cytokines in Rats with Endotoxaemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 130-133.
[1]马超英,周鹃,李海霖,耿耘,唐静雯,彭春荣,涂显琴,徐寅生.大承气汤对内毒素血症大鼠炎性细胞因子的影响[J].中国实验方剂学杂志,2011,17(13):130-133. DOI： 10.13422/j.cnki.syfjx.2011.13.057.

MA Chao-ying1, ZHOU Juan2, LI Hai-lin2, et al. Effect of Dachengqi Decoction on Cytokines Tumor Necrosis Inflammatory Cytokines in Rats with Endotoxaemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 130-133. DOI： 10.13422/j.cnki.syfjx.2011.13.057.

摘要

目的:观察大承气汤对内毒素血症大鼠炎性细胞因子的影响

探讨大承气汤在治疗内毒素血症中的作用机制。方法:SD大鼠50只

随机分为假手术组、模型组、大承气汤组、大黄组、厚朴组。ig剂量按1g·kg-1给予大鼠

大鼠术前给药2d

末次给药1h后

按盲肠结扎穿孔术（CLP）方法造模

术后连续按相同剂量给药3d

测定大鼠血浆内毒素和血清肿瘤坏死因子-α（TNF-α）、白介素-1β（IL-1β）、白介素-10（IL-10）的含量。结果:与模型组相比

各治疗组血浆内毒素含量、血清TNF-α含量均明显降低（P<0.01）;与模型组比较

各治疗组血清IL-1β和IL-10含量均显著降低

差异显著（P<0.01）;IL-1β/IL-10模型组（1.218 6±0.3879）、大承气汤组（0.3891±0.2239）、大黄组（0.3667±0.2489）、厚朴组（0.372 5±0.185 8）亦有明显差异（P<0.01）。结论:大承气汤对内毒素血症的作用机制与拮抗血清炎性细胞因子TNF-α

IL-1β和调节IL-1β/IL-10比值有关。

Abstract

Objective:To observe the effect of Dachengqi Decoction（DT）on inflammatory cytokines in rats suffered from the endotoxemia

and to discuss the mechanism of DT when curing the endotoxemia.Method: Fifty SD rats were divided into 5 groups randomly:sham operation group

model group

DT group

Rhei Radix et Rhizome group and Magnolia officinalis group.Two days before model establishment

rats were intervented by intragastric administration（1 g·kg-1）for the medication groups;and 1 hour after the last drug administration

model was established by CLP

then medication was continued for 3 days.The serum content of endotoxin

TNF-α

IL-1β and IL-10 was detected.Result: The content of plasma endotoxin

TNF-α

IL-1β and IL-10 was decreased evidently in curing group compared with those in the model group（P<0.01）.Concerning IL-1β/IL-10

model group（1.218 6±0.387 9）

DT group（0.389 1±0.223 9）

Radix Et Rhizome Rhea group（0.366 7±0.248 9）

M.officinalis group（0.372 5±0.185 8）

each treatment group compared with model group also had significant difference（P<0.01）.Conclusion: It shows that the mechanism of DT on endotoxemia is related with the antagonistic to the serum inflammatory cytokines TNF-α

IL-1β and the moderating effect to the ratio of IL-1β/IL-10.

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Related Author

MA Chao-ying

ZHOU Juan

LI Hai-lin

GENG Yun

TANG Jing-wen

PENG Chun-rong

TU Xian-qin

XU Yin-sheng

Related Institution

Hubei University of Traditional Chinese Medicine

Wuhan University

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Chengdu University of Traditional Chinese Medicine（TCM）

Affiliated Hospital of Chengdu University of TCM

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