Estrogenic Effect of Psoraleae Fructus in Ovariectomized Rats

WEI Yan-yan1; ZHANG Zi-jia2; XU Ying4; ZHANG Jing-jing1; CHEN Jie2; WANG Zheng-tao1

doi:10.13422/j.cnki.syfjx.2011.13.063

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Estrogenic Effect of Psoraleae Fructus in Ovariectomized Rats

更新时间：2024-09-23

- Estrogenic Effect of Psoraleae Fructus in Ovariectomized Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 158-161(2011)
- 作者机构：
  
  1. 中国药科大学生药学研究室
  2. 上海中医药大学中药研究所中药标准化教育部重点实验室
  3. 上海中药标准化研究中心
  4. 中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.063
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]韦妍妍,张紫佳,徐颖,张菁菁,陈洁,王峥涛.补骨脂对去卵巢大鼠雌激素样作用研究[J].中国实验方剂学杂志,2011,17(13):158-161.

WEI Yan-yan1, ZHANG Zi-jia2, XU Ying4, et al. Estrogenic Effect of Psoraleae Fructus in Ovariectomized Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 158-161.
[1]韦妍妍,张紫佳,徐颖,张菁菁,陈洁,王峥涛.补骨脂对去卵巢大鼠雌激素样作用研究[J].中国实验方剂学杂志,2011,17(13):158-161. DOI： 10.13422/j.cnki.syfjx.2011.13.063.

WEI Yan-yan1, ZHANG Zi-jia2, XU Ying4, et al. Estrogenic Effect of Psoraleae Fructus in Ovariectomized Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 158-161. DOI： 10.13422/j.cnki.syfjx.2011.13.063.

摘要

目的:观察补骨脂对去卵巢大鼠的雌激素样作用。方法:SD雌性大鼠行双侧卵巢摘除术（假手术组只切除卵巢附近脂肪）

随机分为去卵巢模型组、补骨脂组（0.59 g.kg）、补佳乐组（0.8 g×10-4 g·kg-1）和假手术组

ig 4周后分别观察大鼠肛温、子宫和肾上腺系数

ELISA法检测血清雌二醇（E2）、黄体生成素（LH）、促卵泡生成素（FSH）水平。结果:模型组大鼠与假手术组比较肛温升高

子宫和肾上腺萎缩

血清中E2水平下降

FSH水平升高。与模型组比较

补骨脂组、补佳乐组大鼠的肛温明显降低（P<0.01）

子宫和肾上腺系数明显提高（P<0.05

P<0.01）

血中E2浓度明显升高

FSH水平明显降低（P<0.01）。结论:补骨脂能降低去卵巢大鼠的肛温

增加子宫和肾上腺系数

升高血中E2水平并降低LH

FSH水平

表明补骨脂对去卵巢大鼠有雌激素样作用。

Abstract

Objective:To investigate the estrogenic effects of Psoraleae Fructus in ovariectomized rats.Method: Female SD rats were ovariectomized（ovx）and randomly assigned to four groups:ovariectomized without treatment

sham operated

ovx rats treated with 0.08 mg·kg-1 progynova and ovx rats treated with Psoraleae Fructus at dose of 0.59 g·kg-1 for four weeks.The rectal temperature

wet weight of uterus and adrenal gland were observed

levels of estradiol（E2）

luteinizing hormone（LH） and follicle stimulating hormone（FSH） in serum were detected by ELISA.Result: Compared with untreated OVX controls

both Psoraleae Fructus and progynova treatments showed significant and clear estrogenic activity as indicated by increased weight of uterus and adrenal gland

and the reduction in rectal temperature（P<0.01）.Significant increased in serum E2 and decreased in serum LH and FSH were found compared with the untreated OVX controls（P<0.01）.Conclusion: Psoraleae Fructus has estrogenic activity in ovariectomized rats.

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