LIU Sha1, YANG Lin2, PU Xiao-dong1, et al. Effect of Sanjia Powder on Transforming Growth Factor β and Augmenter of Liver Regenration in Rats with Experimental Hepatic Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 174-177.
LIU Sha1, YANG Lin2, PU Xiao-dong1, et al. Effect of Sanjia Powder on Transforming Growth Factor β and Augmenter of Liver Regenration in Rats with Experimental Hepatic Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 174-177. DOI: 10.13422/j.cnki.syfjx.2011.13.068.
Effect of Sanjia Powder on Transforming Growth Factor β and Augmenter of Liver Regenration in Rats with Experimental Hepatic Fibrosis
Objective:To study the molecular mechanism of treatment by Sanjia powder on the hepatic fibrosis in rats.Method: Hepatic fibrosis model of rat was established by administration of CCl4.Rats were divided into model group
malotilate group and low
middle
high dosage groups of Sanjia powder.After eight weeks
the level of transforming growth factor β(TGF-β)
augmenter of liver regenration(ALR)
biochemical and hepatic fibrosis pathology were observed for different groups.Result: The concentrations of HA
LN
PⅢNP
PⅣ in serum and transforming growth factor β
augmenter of liver regenration in liver of model group were higher than those in the control(P<0.01).Compared with the model group
all the Sanjia powder dosage groups could improve the liver function
reduce serum markers of hepatic fibrosis(P<0.05).Conclusion: Sanjia powder inhibited rat hepatic fibrosis induced by CCl4
and the mechanism is likely related to decrease of the expression of TGF-β and ALR.