Investigation of Mechanism of Toxicity Reduction in Compatibility of Crotonis Fructus with Different Dosage Platycodon Grandiflorum

LIN Yan-jun1; FU Chao-mei; ZHANG Jin-ming; GAO Fei; YOU Yu

doi:10.13422/j.cnki.syfjx.2011.13.069

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Investigation of Mechanism of Toxicity Reduction in Compatibility of Crotonis Fructus with Different Dosage Platycodon Grandiflorum

更新时间：2024-09-23

- Investigation of Mechanism of Toxicity Reduction in Compatibility of Crotonis Fructus with Different Dosage Platycodon Grandiflorum
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 178-181(2011)
- 作者机构：
  
  成都中医药大学药学院西部中药材开发与利用教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.069
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]林彦君,傅超美,章津铭,高飞,游宇.基于不同剂量比的巴豆配伍桔梗“减毒”作用机制探讨[J].中国实验方剂学杂志,2011,17(13):178-181.

LIN Yan-jun1, FU Chao-mei, ZHANG Jin-ming, et al. Investigation of Mechanism of Toxicity Reduction in Compatibility of Crotonis Fructus with Different Dosage Platycodon Grandiflorum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 178-181.
[1]林彦君,傅超美,章津铭,高飞,游宇.基于不同剂量比的巴豆配伍桔梗“减毒”作用机制探讨[J].中国实验方剂学杂志,2011,17(13):178-181. DOI： 10.13422/j.cnki.syfjx.2011.13.069.

LIN Yan-jun1, FU Chao-mei, ZHANG Jin-ming, et al. Investigation of Mechanism of Toxicity Reduction in Compatibility of Crotonis Fructus with Different Dosage Platycodon Grandiflorum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 178-181. DOI： 10.13422/j.cnki.syfjx.2011.13.069.

摘要

目的:探索巴豆配伍桔梗是否具有"减毒"作用及其作用机制。方法:以动物死亡状态及半数致死量（LD50）为评价指标

比较巴豆配伍不同剂量比的桔梗前后的动物中毒情况;通过测定比较巴豆配伍桔梗的不同剂量比下巴豆苷含量

从化学成分角度揭示巴豆配伍桔梗"减毒"作用机制。结果:巴豆配伍不同剂量比桔梗

其毒性反应均减小

且以1∶3剂量比值下LD50及其95%可行限抬高最多;同时配伍不同剂量比桔梗后巴豆苷含量呈现"抛物线"式变化

在1∶3剂量比时巴豆苷含量降低最多（32.57%）。结论:巴豆配伍桔梗（1∶3）剂量比值为其减毒作用最佳比值

可能与其减少了游离态巴豆苷含量有关。

Abstract

Objective:To explore whether there is the effect of Platycodon grandiflorum on the reduction of the acute toxicity of Crotonis Fructus

and the mechanism of this effect.Method: The death condition and LD50 were used to be the index to evaluate the toxic conditions in the compatibility Crotonis Fructus with different dosage of P.grandiflorum.Furthermore

we revealed the mechanism of toxicity reduction via determining the content of crotonoside in the compatibility Crotonis Fructus with different dosage of P.grandiflorum.Result: The toxicity of Crotonis Fructus was reduced after the compatibility of P.grandiflorum

especially when dosage ratio between Crotonis Fructus and P.grandiflorum is 1∶3

the degree of LD50 and the 95% confidence level elevation was biggest.Besides

after the compatibility of P.grandiflorum

the content of crotonoside was changed as parabola

which elevated firstly and reduced then.The result showed the content of crotonoside reduced 32.57%

with masimum degree

when the dosage ratio is 1∶3.Conclusion: 1∶3 of the dosage ratio is the best ratio for reducing the toxicity of Crotonis Fructus in the compatibility of P.grandiflorum.And the effect may relate to the reduction of free-state crotonoside.

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Related Author

LIN Yan-Jun

FU Chao-mei

ZHANG Jin-ming

GAO Fei

YOU Yu

CHEN Yaman

CUI Jinpeng

ZHANG Juan

Related Institution

College of Agronomy， Henan Agricultural University

Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine， Henan University of Chinese Medicine

Beijing University of Chinese Medicine

School of Traditional Chinese Medicine（TCM），Shanghai University of TCM

School of Chinese Materia Medica， Beijing University of Chinese Medicine

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