Effects of Kangxian Yixin Formula on Plasma Angiotensin Ⅱ and Aldosterone in Rats with Dilated Cardiomyopathy

WEI Jing-mei; WANG Zhen-tao; CHAI Song-bo; LI Bo-hai

doi:10.13422/j.cnki.syfjx.2011.13.074

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Effects of Kangxian Yixin Formula on Plasma Angiotensin Ⅱ and Aldosterone in Rats with Dilated Cardiomyopathy

更新时间：2024-09-23

- Effects of Kangxian Yixin Formula on Plasma Angiotensin Ⅱ and Aldosterone in Rats with Dilated Cardiomyopathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 195-197(2011)
- 作者机构：
  
  河南省中医院心血管病研究室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.074
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]魏景梅,王振涛,柴松波,李伯海.抗纤益心方对扩张型心肌病大鼠血浆血管紧张素Ⅱ和醛固酮的影响[J].中国实验方剂学杂志,2011,17(13):195-197.

WEI Jing-mei, WANG Zhen-tao, CHAI Song-bo, et al. Effects of Kangxian Yixin Formula on Plasma Angiotensin Ⅱ and Aldosterone in Rats with Dilated Cardiomyopathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 195-197.
[1]魏景梅,王振涛,柴松波,李伯海.抗纤益心方对扩张型心肌病大鼠血浆血管紧张素Ⅱ和醛固酮的影响[J].中国实验方剂学杂志,2011,17(13):195-197. DOI： 10.13422/j.cnki.syfjx.2011.13.074.

WEI Jing-mei, WANG Zhen-tao, CHAI Song-bo, et al. Effects of Kangxian Yixin Formula on Plasma Angiotensin Ⅱ and Aldosterone in Rats with Dilated Cardiomyopathy[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 195-197. DOI： 10.13422/j.cnki.syfjx.2011.13.074.

摘要

目的:探讨抗纤益心方抑制扩张型心肌病（DCM）大鼠血浆血管紧张素Ⅱ和醛固酮的机制。方法:采用自主饮用呋喃唑酮水溶液（按1 kg水加700 mg呋喃唑酮配置）建立DCM大鼠模型

分为模型组、抗纤益心方高、低剂量组、卡托普利对照组、中西药联用组。每日分别给予生理盐水

抗纤益心方18.8

4.7 g·kg-1

卡托普利10.125 mg·kg-1

抗纤益心方高剂量和卡托普利混合溶液

ig干预8周

用放射免疫法检测血浆血管紧张素Ⅱ和醛固酮含量。结果:模型组大鼠血浆中血管紧张素Ⅱ（159.94±12.03）ng·L-1和醛固酮（1.23±0.09）μg·L-1明显高于正常组（69.47±7.79）ng·L-1和（0.34±0.11）μg·L-1（P<0.05）;与模型组比较

所有给药组（抗纤益心方小剂量组除外）血浆中血管紧张素Ⅱ和醛固酮明显下降（P<0.05）;抗纤益心方18.8 g·kg-1组与卡托普利10.125 mg·kg-1组相比无显著差异

血管紧张素Ⅱ分别为（85.23±5.18）

（87.90±6.02）ng·L-1

醛固酮分别为（0.69±0.06）

（0.74±0.42）μg·L-1（P>0.05）

与中西药联用组比较有统计学意义（P<0.05）

与小剂量组比较有显著差异（P<0.05）。结论:抗纤益心方能够干预扩张型心肌病大鼠左室重构

其作用可能与抑制血浆中血管紧张素Ⅱ及醛固酮的水平有关。

Abstract

Objective:To investigate the mechanism of Kangxian Yixin Formula（KXYXF）for inhibiting plasma aldosterone and angiotensin Ⅱin rats with dilated cardiomyopathy（DCM）.Method: Free drinking of furazolidone solution（700 mg furazolidone in 1kg of water）was used to establish DCM in rats.The rats were divided into model group

KXYXF high-dose group

KXYXF low-dose group

captopril control group.KXYXF combined with captopril group.The rats were accordingly treated daily with normal saline

KXYXF 18.8 g·kg-1

KXYXF 4.7 g·kg-1

captopril 10.125 mg·kg-1

KXYXF 18.8 g·kg-1combined with captopril 10.125 mg·kg-1ig for 8 weeks.Plasma angiotensin Ⅱ and aldosterone were determined by radioimmunoassay.Result: Aldosterone and plasma Ang Ⅱ were higher in the model group and compared with those in normal group[（159.94±12.03） vs（69.47±7.79） ng·L-1 and（1.23±0.09） vs（0.34±0.11） μg·L-1accordingly

both P<0.05].Compared with the model group

angiotensin Ⅱ and aldosterone in all treated groups（except KXYXF low dose group）were significantly decreased（P<0.05）;while the KXYXF high-dose group and the captopril group showed no significant difference（85.23±5.18） vs（87.90±6.02） ng·L-1 and（0.69±0.06） vs（0.74±0.42） μg·L-1 respectively).The KXYXF combined with captopril group showed statistically significant（P<0.05）

the KXYXF low dose group was also significant（P<0.05）.Conclusion: KXYXF can interfere with dilated left ventricular remodeling in rats with dilated cardiomyopathy（DCM）.This may be related to the inhibition of plasma angiotensin Ⅱ and aldosterone.

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WEI Jing-mei

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LI Bo-hai

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Ling-yan SONG

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Related Institution

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