Antioxidant Effect of Flavonoids from Uraria crinita

LUO Chao; LIU Ai-ming; XING Wei-qing; SHI Guang; CAO Ying; PANG Jian-xin; QIU Yu-chang

doi:10.13422/j.cnki.syfjx.2011.13.075

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Antioxidant Effect of Flavonoids from Uraria crinita

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- Antioxidant Effect of Flavonoids from Uraria crinita
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 198-201(2011)
- 作者机构：
  
  南方医科大学药学院新药评价中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.075
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]罗超,刘霭明,邢惟青,石光,曹莹,庞建新,丘玉昌.石参总黄酮抗氧化活性研究[J].中国实验方剂学杂志,2011,17(13):198-201.

LUO Chao, LIU Ai-ming, XING Wei-qing, et al. Antioxidant Effect of Flavonoids from Uraria crinita[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 198-201.
[1]罗超,刘霭明,邢惟青,石光,曹莹,庞建新,丘玉昌.石参总黄酮抗氧化活性研究[J].中国实验方剂学杂志,2011,17(13):198-201. DOI： 10.13422/j.cnki.syfjx.2011.13.075.

LUO Chao, LIU Ai-ming, XING Wei-qing, et al. Antioxidant Effect of Flavonoids from Uraria crinita[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 198-201. DOI： 10.13422/j.cnki.syfjx.2011.13.075.

摘要

目的:研究石参总黄酮的抗氧化活性。方法:采用50%乙醇回流冷凝提取石参根

提取液分别用乙醚和乙酸乙酯萃取

得到石参总黄酮。利用2

2-联氮-二（3-乙基-苯并噻唑-6-磺酸）二铵盐[2

2’-azinobis-（3-ethylbenzthiazoline-6-sulphonate）

ABTS]法检测总抗氧化能力

采用分光光度法检测对1

1-二苯基-2-苦味肼基（1

1-Diphenyl-2-picrylhydrazy

DPPH）

羟基自由基（.OH）、一氧化氮（NO）的清除作用及对脂质过氧化的抑制作用。结果:石参总黄酮在20～100 mg·L-1对DPPH

ABTS+

.OH和NO等自由基具有明显的清除作用

最大清除率分别达到60.89%

74.87%

41.77%

81.01%;对脂质过氧化亦有明显的抑制作用

最大抑制率达41.07%

并具有浓度依赖性。结论:石参总黄酮具有较好的清除自由基活性和抑制脂质过氧化的作用。

Abstract

Objective:To investigate the radical scavenging effect of flavonoids from U.crinita.Method: Flavonoids were obtained from U.crinita root by extraction with 50% ethanol

ether and ethyl acetate.Total antioxidant activity was investigated by 2

2′-Azinobis-（3-ethylbenzthiazoline-6-sulphonate）（ABTS）.The abilities of scavenging 1

1-diphenyl-2-picrylhydrazy（DPPH）

·OH and NO

as well as the inhibitory effect of lipid peroxidation were studied through ultraviolet spectrophotometry in vitro.Result: Flavonoids from U.crinita

ranging from 20-100 μg·mL-1

sharply scavenged the DPPH

ABTS+

·OH

and inhibited lipid peroxidation dose dependently.Conclusion: Flavonoids from U.crinita shows potent ability in scavenging radicals and inhibiting lipid peroxidation.

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Related Author

LUO Chao

LIU Ai-ming

XING Wei-qing

SHI Guang

CAO Ying

PANG Jian-xin

QIU Yu-chang

ZHANG Haotian

Related Institution

The First Affiliated Hospital， Jinan University

School of Traditional Chinese Medicine， Jinan University

Changhai Hospital， Naval Medical University

School of Pharmacy，Anhui University of Chinese Medicine & Laboratory of Rearch and Development of Traditional Chinese Medicine in Anhui Province

Gansu Provincial Hospital of Traditional Chinese Medcine

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