This article summarizes its pharmacological effects

toxicity

and adverse reactions

reported in the literatures in recent some 20 years.Modern pharmacological study has proved its multiple function

such as anti-bacteria

anti-inflammatory

anti-virus

anti-tumor

enhancing immunity etc

the main clinical indication includes thrombocytopenic purpura

acute and chronic nephritis

renal edema and psoriasis.Among them

the actions of anti-inflammatory and immunity are prominent.Polysaccharides and saponins could extensively regulate many cytokines.At present

clinical reports on acute poisoning have been found.Patients all show sympathetic nerve excitement and gastrointestinal irritation with different degrees.Toxic performances were related to digestive

central nervous

cardiovascular

respiratory and other systems.Death could be induced as serious toxicity happened.Animal experiments have also confirmed its toxicity

including potential mutagenicity.Therefore

for safety and effectiveness in the clinic

further research and attention should be paid to the adverse responses of Phytolaccae and the approach of decreasing the toxicity.