Research Progress on Analysis of Strychnos nux-vomica in vitro and in vivo

WANG Xuan1; CHEN Jun1; CAI Bao-chang2

doi:10.13422/j.cnki.syfjx.2011.13.079

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Research Progress on Analysis of Strychnos nux-vomica in vitro and in vivo

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- Research Progress on Analysis of Strychnos nux-vomica in vitro and in vivo
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 258-262(2011)
- 作者机构：
  
  1. 南京中医药大学药学院
  2. 江苏省中药炮制重点实验室
  3. 南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心
  4. 国家中医药管理局中药炮制标准重点研究实验室
  5. 南京海昌中药集团
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.079
  CLC： R284
- Published：2011
- 稿件说明：
移动端阅览
[1]王绚,陈军,蔡宝昌.马钱子体内外分析研究进展[J].中国实验方剂学杂志,2011,17(13):258-262.

WANG Xuan1, CHEN Jun1, CAI Bao-chang2. Research Progress on Analysis of Strychnos nux-vomica in vitro and in vivo[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 258-262.
[1]王绚,陈军,蔡宝昌.马钱子体内外分析研究进展[J].中国实验方剂学杂志,2011,17(13):258-262. DOI： 10.13422/j.cnki.syfjx.2011.13.079.

WANG Xuan1, CHEN Jun1, CAI Bao-chang2. Research Progress on Analysis of Strychnos nux-vomica in vitro and in vivo[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 258-262. DOI： 10.13422/j.cnki.syfjx.2011.13.079.

摘要

从药物分析的角度出发

针对近10年来国内外马钱子中士的宁和马钱子碱的主要体内外分析方法作一汇总。全文主要从液相色谱法、气质联用法、液质联用法、荧光光谱法、薄层色谱法、毛细管电泳色谱法等多个方面进行简介。结果作者认为

不同的分析方法都有其优点

其中光谱法、色谱法一直是马钱子体内外分析最强有力的手段。荧光分析法优点是灵敏度高

选择性好;薄层色谱法优点在于简单

经济;高效毛细管电泳法分离模式多

分离效率高

速度快;HPLC十分常用

具有分离效能高、分析速度快等特点;而色谱与质谱的联用是应用于药物分析中最为活跃的技术

它集LC的高分离能力与MS的高灵敏度、高专属性于一体

能够使马钱子样品的分离、定性、定量一次完成。现有研究表明色谱与质谱的联用及毛细管电泳中的各种在线预浓缩技术是目前应用于马钱子体内外分析中最为活跃的技术。

Abstract

In the present paper

the general situation of analysis on Strychnos nux-vomica.in vitro and in vivo at home and abroad in a decade was summarized from the perspective of drug analysis.It was feasible for application to routine quality control

preliminary screening of trace levels of S.nux-vomica for pharmacokinetic study

forensic analysis as well as doping control.In the light of HPLC

GC-MS

HPLC-MS

HTLC

HPCE etc

comparisons among different analysis were conducted.Furthermore

it was demonstrated that Chromatography-Mass spectrometry and on-line pre-enrichment technology are actively used in analysis on S.nux-vomica in vitro and in vivo currently.

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Related Author

CAI Bao-chang

Chen Jun

WANG Xuan

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DENG Ru-ming1

SU Qing1

CHEN Yan-jun2

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Related Institution

State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences, Peking University Health Science Center

Center of Scientific Experiment,Beijing University of Chinese Medicine

Chengdu University of Traditional Chinese Medicine

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