Establishment and Evaluation of Rat Model of Metabolic Syndrome with Abnormal Glucose Metabolism

JIANG Nan1; SHI Yan1; PU Ji2; ZHANG Wen-shun1; ZHANG Bing-bing1; MA Xian-de1

doi:10.13422/j.cnki.syfjx.2011.13.088

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Establishment and Evaluation of Rat Model of Metabolic Syndrome with Abnormal Glucose Metabolism

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- Establishment and Evaluation of Rat Model of Metabolic Syndrome with Abnormal Glucose Metabolism
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 141-144(2011)
- 作者机构：
  
  1. 辽宁中医药大学
  2. 2. 沈阳市于洪区机构编制委员会
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.088
  CLC： R-332
- Published：2011
- 稿件说明：
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[1]姜楠,石岩,蒲纪,张文顺,张冰冰,马贤德.糖代谢异常的代谢综合征大鼠模型的建立及评价[J].中国实验方剂学杂志,2011,17(13):141-144.

JIANG Nan1, SHI Yan1, PU Ji2, et al. Establishment and Evaluation of Rat Model of Metabolic Syndrome with Abnormal Glucose Metabolism[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 141-144.
[1]姜楠,石岩,蒲纪,张文顺,张冰冰,马贤德.糖代谢异常的代谢综合征大鼠模型的建立及评价[J].中国实验方剂学杂志,2011,17(13):141-144. DOI： 10.13422/j.cnki.syfjx.2011.13.088.

JIANG Nan1, SHI Yan1, PU Ji2, et al. Establishment and Evaluation of Rat Model of Metabolic Syndrome with Abnormal Glucose Metabolism[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 141-144. DOI： 10.13422/j.cnki.syfjx.2011.13.088.

摘要

目的:建立糖代谢异常的代谢综合征大鼠模型及其评价标准。方法:采用高脂高盐高糖饮食配合饮用蔗糖水喂养Wistar雄性大鼠12周

喂养结束后检测其体重、血压、血糖、甘油三酯、高密度脂蛋白及胰岛素水平。根据中华医学会糖尿病学分会关于代谢综合征（MS）的诊断标准和统计学原理建立模型评价标准。结果:第8周开始

高脂高糖高盐膳食组大鼠体重（367±17）g和收缩压（130.67±4.31）mmHg与普通膳食对照组比较显著升高（P<0.01）;第12周时

大鼠空腹血糖（10.51±0.89）mmol·L-1、甘油三酯（1.63±0.23）mmol·L-1、胰岛素水平（1.97±1.07）mmol·L-1显著升高（P<0.01或P<0.05）

高密度脂蛋白（0.54±0.07）mmol·L-1显著降低（P<0.01）。根据评价标准

模型成功率达到80%。结论:实验成功建立了糖代谢异常的MS大鼠模型

并初步建立了该模型的评价标准。

Abstract

Objective:To establish and to evaluate rat model of metabolic syndrome（MS） with abnormal glucose metablism.Method: Wistar male rats were fed with a diet of high fat

salt and sugar for 12 weeks.Afterwards

body weight

blood pressure

blood glucose

triglycerides

high density lipoprotein and insulin level were determined.According to the MS diagnostic criteria established by Chinese Diabetes Society（CDS） and statistical theory

the model was evaluated.Result: In the first 8 weeks

rats were significantly increased body weight and systolic blood pressure;in the first 12 weeks

fasting blood glucose

triglycerides

insulin level were significantly elevated

high-density lipoprotein significantly reduced.Based on the evaluation criteria

a success rate of 80% for the model was found.Conclusion: We successfully established the rat model of MS with abnormal glucose metabolism

and also the preliminary evaluation criteria for the model.

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Related Author

JIANG Nan

SHI Yan

PU Ji

ZHANG Wen-shun

ZHANG Bing-bing

MA Xian-de

ZHOU Manli

WANG Liping

Related Institution

Hunan University of Medicine

Hunan University of Chinese Medicine

First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Heilongjiang University of Chinese Medicine

Hunan Brain Hospital （The Second People's Hospital of Hunan Province）

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