Overview of Drugs Loaded in Drug Eluting Stents

ZHANG Hai-yan1; WU Wei-kui1; YANG Ming1

doi:10.13422/j.cnki.syfjx.2011.13.089

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Overview of Drugs Loaded in Drug Eluting Stents

更新时间：2024-09-23

- Overview of Drugs Loaded in Drug Eluting Stents
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 13, Pages: 252-258(2011)
- 作者机构：
  
  1. 江西中医学院现代中药制剂教育部重点实验室
  2. 西南交通大学材料先进技术教育部重点实验室
  3. 成都中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.13.089
  CLC： R541.4
- Published：2011
- 稿件说明：
移动端阅览
[1]张海燕,邬伟魁,杨明.药物洗脱支架载药概述[J].中国实验方剂学杂志,2011,17(13):252-258.

ZHANG Hai-yan1, WU Wei-kui1, YANG Ming1. Overview of Drugs Loaded in Drug Eluting Stents[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 252-258.
[1]张海燕,邬伟魁,杨明.药物洗脱支架载药概述[J].中国实验方剂学杂志,2011,17(13):252-258. DOI： 10.13422/j.cnki.syfjx.2011.13.089.

ZHANG Hai-yan1, WU Wei-kui1, YANG Ming1. Overview of Drugs Loaded in Drug Eluting Stents[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 252-258. DOI： 10.13422/j.cnki.syfjx.2011.13.089.

摘要

主要对药物洗脱支架载药方面的国内外研究进行文献整理和分析。近年来

冠心病发病率呈逐年上升趋势。冠心病介入治疗经历了经皮冠状动脉腔内成形术（PTCA）、裸金属支架（BMS）和药物洗脱支架（Drug eluting stent

DES）3个阶段。较之裸支架

目前使用的雷帕霉素和紫杉醇洗脱支架系统在一定程度上降低了再狭窄率;但是

抗增生药物可延迟血管内皮化

导致晚期支架内血栓的形成。探讨了雷帕霉素及其衍生物（他克莫司、依维莫司、佐他莫司、Mytrolimus）、紫杉醇等抗增生药物的优缺点和中药（川芎嗪、大黄素、姜黄素、雷公藤内酯醇、葛根素等）血管支架的潜在价值

以期为研发新型的药物洗脱支架提供参考。认为具有多靶点、多途径调节作用的心脑血管中药成分或将成为新一代支架载药研究热点

紧密结合材料学

中医药在防治血管再狭窄方面将取得更大突破。

Abstract

Drugs loaded in drug eluting stents（DESs） were introduced in this review.DESs have been dominant for the treatment of coronary artery disease in the interventional cardiology world owing to their preponderance in reducing restenosis.However

late in-stent thrombosis has become a major concern.Aiming to provide a clue for the design of future DES

this review focuses on the development of drugs（rapamycin

tacrolimus

everolimus

mytrolimus

taxinol） loaded in DESs and their roles in restenosis and thrombosis.Currently

there is insufficient information to evaluate the safety and efficacy of herbal medicine loaded in DESs for clinical use.Traditional Chinese Medicines（TCMs） have been extensively used to prevent and cure many diseases in China due to its low toxicity and rare complications.If herbal extracts（tetramethylpyrazine

emodin

curcumine

triptolide

puerarin

etc.） were loaded in DESs

the restenosis and thrombosis rate would decrease.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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