LI Xue-min, WU Qing, DU Shou-ying, et al. Formula of Chuanzhi Microemulsion by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 1-5.
LI Xue-min, WU Qing, DU Shou-ying, et al. Formula of Chuanzhi Microemulsion by Box-Behnken Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 1-5. DOI: 10.13422/j.cnki.syfjx.2011.15.014.
Formula of Chuanzhi Microemulsion by Box-Behnken Design
Objective:The purpose of the present study was to investigate the fessibility that the essential oilas the oil phase of the microemulsion and optimize the formula of Chuan zhi microemulsion.Method:The pseudoternary phase diagrams were developed for various microemulsion formulations.The microemulsion was optimized using a three-factor
three-level Box-Behnken design.The independent variables selected were surfactant
co-surfactant and oil;dependent variables(responses) were polydispersity index(PDI).Mathematical equations and response surface plots were used to relate the dependent and independent variables.Optimized formulation factors were selected by feasibility and grid search.Result:Validation test showed that the average particle size of antalgic microemulsion was(13.17 ± 0.07) nm.Conclusion:The essential oil can be the oil phase of the microemulsion.The Box-Behnken design can optimize the formulation objectively.
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Related Author
LI Xue-min
WU Qing
DU Shou-ying
GONG Wei-hong
YANG Sheng
ZHANG Ding-kun
SU Zhe-tong
XU Jia-li
Related Institution
School of Pharmacy,State Key Laboratory of Southwest Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine
Beijing City University
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Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
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