Research on Good Usage Practice for Chinese Materia Medica（Ⅱ）:Pharmacological Equivalence of Different Preparing Procedures and Optimal Conditions for Clinical Usage of Rhubarb

LIU Fei-fei1; WANG Jia-bo1; XIA Xin-hua2; JIN Cheng1; ZHOU Can-ping1; ZHANG Xue-ru1; XIAO Xiao-he1

doi:10.13422/j.cnki.syfjx.2011.15.016

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Research on Good Usage Practice for Chinese Materia Medica（Ⅱ）:Pharmacological Equivalence of Different Preparing Procedures and Optimal Conditions for Clinical Usage of Rhubarb

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- Research on Good Usage Practice for Chinese Materia Medica（Ⅱ）:Pharmacological Equivalence of Different Preparing Procedures and Optimal Conditions for Clinical Usage of Rhubarb
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 10-13(2011)
- 作者机构：
  
  1. 解放军302医院全军中药研究所
  2. 湖南中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.016
  CLC： R283
- Published：2011
- 稿件说明：
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[1]刘斐斐,王伽伯,夏新华,金城,周灿平,张学儒,肖小河.中药调剂规范化研究(Ⅱ)大黄不同调剂处理的等效性比较及条件优选[J].中国实验方剂学杂志,2011,17(15):10-13.

LIU Fei-fei1, WANG Jia-bo1, XIA Xin-hua2, et al. Research on Good Usage Practice for Chinese Materia Medica（Ⅱ）:Pharmacological Equivalence of Different Preparing Procedures and Optimal Conditions for Clinical Usage of Rhubarb[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 10-13.
[1]刘斐斐,王伽伯,夏新华,金城,周灿平,张学儒,肖小河.中药调剂规范化研究(Ⅱ)大黄不同调剂处理的等效性比较及条件优选[J].中国实验方剂学杂志,2011,17(15):10-13. DOI： 10.13422/j.cnki.syfjx.2011.15.016.

LIU Fei-fei1, WANG Jia-bo1, XIA Xin-hua2, et al. Research on Good Usage Practice for Chinese Materia Medica（Ⅱ）:Pharmacological Equivalence of Different Preparing Procedures and Optimal Conditions for Clinical Usage of Rhubarb[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 10-13. DOI： 10.13422/j.cnki.syfjx.2011.15.016.

摘要

目的:基于等效性探讨大黄饮片粒度规格及调剂学处理对临床合理用药的影响规律。方法:比较研究大黄不同提取粒度（3～15μm）、提取时间（15～120 min）、提取次数（1～6次）、不同提取溶剂（水和70%乙醇）、先下/后下处理方式对便秘小鼠排便总量的影响。结果:大黄水/醇提不同粒度饮片时泻下活性最高差别4.5/2.0倍;水/醇提不同时间最高差别1.7/1.7倍;水/醇提不同次数最高差别1.3/2.4倍;水/醇提先下和后下最高差别1.9/1.4倍。从等效性来看

大黄药材不同饮片规格、不同提取溶剂、不同提取时间、不同提取次数、先/后下均对其泻下生物活性有较大影响。结论:不同调剂处理方式对大黄样品间泻下活性有显著影响;应高度重视调剂处理可能对临床疗效的影响

亟待建立科学、严格的中药调剂操作规范。

Abstract

Objective:To probe into the influences of different granule sizes and preparing procedures to rational clinical usage of rhubarb based on pharmacological equivalence.Method:The pharmacological equivalence of different preparing procedures

particle size（3-15 μm）

extract solvent（water and 70% alcohol）

extract time（15-20 min） and repeat times（1-6 times）

and pre-extracting or post-extracting

of rhubarb were compared regarding the defecation mass of constipated mice.Result:When extracted with water or ethanol

the maximum variations of laxative activities of rhubarb pieces in different sizes were of 4.5 or 2.0 times.Such variations of different preparing procedures

extract time

repeat times of extraction and pre-or post-extracting

were 1.7 or 1.7 times

1.3 or 2.4 times

1.9 or 1.4 times

respectively.The different preparing procedures investigated in the paper revealed significant influence to the laxative activities and those extracts were not pharmacological equivalent.When the rhubarb samples were extracted with water

the laxative activities in different repeat times of extraction revealed less difference while the post-extraction procedure revealed higher laxative activities than pre-extraction.Conclusion:The different preparing procedures for rhubarb showed significant influence to the laxative activities.The influence by clinical preparing procedures should be emphasized and the standard operation procedures（SOP） are need to be established.

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Related Author

LIU Fei-fei

WANG Jia-bo

XIA Xin-hua

JIN Cheng

ZHOU Can-ping

ZHANG Xue-ru

XIAO Xiao-he

WEI Feng-ling

Related Institution

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Shaanxi Martial Police Army Hospital

Pharmaceutical Department of North China Coal Medical University

College of Chinese Materia Medica,Guangdong Pharmaceutical University

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