Formulation Technology of Chonglou Kegan Dropping Pills

YANG Pei-min1; NI Jian1; CAO Guang-shang2; WEI Yong-li2

doi:10.13422/j.cnki.syfjx.2011.15.018

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Formulation Technology of Chonglou Kegan Dropping Pills

更新时间：2024-09-23

- Formulation Technology of Chonglou Kegan Dropping Pills
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 18-20(2011)
- 作者机构：
  
  1. 北京中医药大学
  2. 山东中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.018
  CLC： R283
- Published：2011
- 稿件说明：
移动端阅览
[1]杨培民,倪健,曹广尚,魏永利.重楼克感滴丸成型工艺[J].中国实验方剂学杂志,2011,17(15):18-20.

YANG Pei-min1, NI Jian1, CAO Guang-shang2, et al. Formulation Technology of Chonglou Kegan Dropping Pills[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 18-20.
[1]杨培民,倪健,曹广尚,魏永利.重楼克感滴丸成型工艺[J].中国实验方剂学杂志,2011,17(15):18-20. DOI： 10.13422/j.cnki.syfjx.2011.15.018.

YANG Pei-min1, NI Jian1, CAO Guang-shang2, et al. Formulation Technology of Chonglou Kegan Dropping Pills[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 18-20. DOI： 10.13422/j.cnki.syfjx.2011.15.018.

摘要

目的:研究重楼克感滴丸的成型工艺。方法:以滴丸的溶散时限、丸重偏差和外观质量作为评价指标

在单因素试验的基础上采用正交试验法对基质组成、药粉与基质配比、药液温度和滴头滴距等进行筛选。结果:优选的最优工艺参数为PEG 4000与PEG 6000的配比为4∶1

药物细粉与基质的比例为1∶4

滴制温度85℃

滴距6 cm。滴丸的溶散时限、丸重差异和外观质量均满足要求。结论:工艺简明可行

滴丸成型性好

适宜工业化生产。

Abstract

Objective:To optimize the formulation technology of Chonglou Kegan dropping pills.Method:On the basis of preliminary experiment

the formulation technology was selected among sort of the ratio of extractum to matrix

component of matrix

temperature of drug and drop distance

and all the procedures were evaluated by the dissolving scattered limit

weight difference

the appearance and quality of the dropping pills by means of orthogonal experimental method.Result:The optimized procedure parameters were as follows:PEG 4 000 to PEG 6 000（4:1） was used as base material with the ratio of extractum to base material at 1:4;the temperature of the drug was at 85 ℃ and the drop distance was 6cm.Conclusion:The technology is simple and feasible

and suitable for industrial production.

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