Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins

WANG Guang-ming1; PAN Yan2; KONG Qiu-ling2; TIAN Jun2

doi:10.13422/j.cnki.syfjx.2011.15.019

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Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins

更新时间：2024-09-23

- Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 21-23(2011)
- 作者机构：
  
  1. 广东食品药品职业学院
  2. 广州中医药大学中药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.019
  CLC： R283
- Published：2011
- 稿件说明：
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[1]王光明,潘艳,孔秋玲,田军.羟丙基-β-环糊精包合对细辛脑脑靶向生物利用度的影响[J].中国实验方剂学杂志,2011,17(15):21-23.

WANG Guang-ming1, PAN Yan2, KONG Qiu-ling2, et al. Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 21-23.
[1]王光明,潘艳,孔秋玲,田军.羟丙基-β-环糊精包合对细辛脑脑靶向生物利用度的影响[J].中国实验方剂学杂志,2011,17(15):21-23. DOI： 10.13422/j.cnki.syfjx.2011.15.019.

WANG Guang-ming1, PAN Yan2, KONG Qiu-ling2, et al. Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 21-23. DOI： 10.13422/j.cnki.syfjx.2011.15.019.

摘要

目的:考察羟丙基-β-环糊精包合对细辛脑脑靶向生物利用度的影响。方法:以家兔鼻腔分别灌流细辛脑羟丙基-β-环糊精溶液剂与细辛脑水饱和溶液剂进行比较

考察羟丙基-β-环糊精包合细辛脑后药物的生物利用度。结果:羟丙基-β-环糊精溶液家兔鼻腔灌流后

家兔血液、嗅脑、大脑、筛鼻甲部位的吸收量均高于水饱和溶液

具有统计学意义。结论:细辛脑与羟丙基-β-环糊精形成包合物

经兔鼻腔灌流后

家兔血液、嗅脑、筛鼻甲、大脑吸收量均高于水饱和溶液

细辛脑的生物利用度得到提高。

Abstract

Objective:To observe the bioavailability of α-asarone by its inclusion complex of hydroxypropylcyclodextrins.Method:Rabbits were divided into two groups according to different solvents.The bioavailability of α-asarone was compared between the inclusion complex of hydroxypropylcyclodextrins group and water solution group in blood drug concentration

the content of ethmoidal concha

cerebral and olfactory brain.Result:The content of α-asarone in blood

olfactory brain

ethmoidal concha and cerebral has higher solubility in the inclusion complex of hydroxypropylcyclodextrins group than that in the water solution group.Conclusion:α-asarone has higher solubility in the inclusion complex of hydroxypropylcyclodextrins group than that in the water solution group.

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WANG Guang-ming

PAN Yan

KONG Qiu-ling

TIAN Jun

GAO Jie

LI Shiyang

GUO Jing

LI Rongsheng

Related Institution

Wuya College of Innovation，Shenyang Pharmaceutical University

Suzhou Youseen New Drug Research&Development Co. Ltd.

School of Pharmacy，Soochow University

School of Chinese Materia Medica，Shanghai University of Traditional Chinese Medicine

School of Pharmacy，Fujian University of Traditional Chinese Medicine

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