LV Jie, LU Xiao-hui, LIANG Mei-yi, et al. Preparation and Dissolution Study of Dispersible Tablets of Zanthoxylum nitidum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 36-40.
LV Jie, LU Xiao-hui, LIANG Mei-yi, et al. Preparation and Dissolution Study of Dispersible Tablets of Zanthoxylum nitidum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 36-40. DOI: 10.13422/j.cnki.syfjx.2011.15.023.
Preparation and Dissolution Study of Dispersible Tablets of Zanthoxylum nitidum
Objective:To examine a suitable formulation for the dispersible tablets of Zanthoxylum nitidum and study the preparation process.Method:The preparative process was scanned out by single factor test and orthogonal design.A comprehensive scoring analysis was performed with disintegrating time and dissolution as the indexes.Result:The optimized dispersible tablets disintegrated in 20 seconds
and the dispersible uniform was excellent.The released rate parameters of dispersible tablets were remarkably smaller than of the control group(P<0.01).Conclusion:Dispersible tablets of Zanthoxylum nitidum had the characteristic of fast and homogeneously dispersing and quick releasing of active constituents.
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Related Author
LV Jie
LU Xiao-hui
LIANG Mei-yi
HUANG Yun-ran
ZHOU Yi-sheng
HAN Ling-ling
HU Rong-feng
LI Hai-yan1
Related Institution
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine, Key Laboratory of Scientific Preparation for Clinical Effective Prescription of State Administration of Traditional Chinese Medicine
Drug Research Center for Nephropathy,Guangzhou Consun Pharmaceutical Co.Ltd