Quality Standard of Yiganqing Sustained-released Tablet

WANG Xing; ZHANG Wei-guo; LI Ying; LI Xiao-qian; WANG Ping; LEI Lei

doi:10.13422/j.cnki.syfjx.2011.15.043

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Quality Standard of Yiganqing Sustained-released Tablet

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- Quality Standard of Yiganqing Sustained-released Tablet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 105-107(2011)
- 作者机构：
  
  西南交通大学生命科学与工程学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.043
  CLC： R286
- Published：2011
- 稿件说明：
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[1]王兴,张卫国,李莹,李晓倩,王萍,雷磊.乙肝清缓释片质量标准[J].中国实验方剂学杂志,2011,17(15):105-107.

WANG Xing, ZHANG Wei-guo, LI Ying, et al. Quality Standard of Yiganqing Sustained-released Tablet[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 105-107.
[1]王兴,张卫国,李莹,李晓倩,王萍,雷磊.乙肝清缓释片质量标准[J].中国实验方剂学杂志,2011,17(15):105-107. DOI： 10.13422/j.cnki.syfjx.2011.15.043.

WANG Xing, ZHANG Wei-guo, LI Ying, et al. Quality Standard of Yiganqing Sustained-released Tablet[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 105-107. DOI： 10.13422/j.cnki.syfjx.2011.15.043.

摘要

目的:建立乙肝清缓释片的质量标准。方法:采用薄层色谱法（TLC）对制剂中的贯叶连翘进行鉴别;采用高效液相色谱法（HPLC）测定制剂中的金丝桃素含量

Phenomenence Luna C18色谱柱（4.6 mm×250 mm

5μm）

流动相乙腈-0.025mol.L-1 KH2 PO4水溶液（85∶15）

检测波长588 nm。并对制剂进行释放度考察。结果:TLC图谱分离度好

检出斑点清晰;金丝桃素在0.076～0.76μg呈良好的线性关系

r=0.999 9

平均回收率98.66%

RSD 2.51%。结论:该法操作简便、可行

重复性好

可作为乙肝清缓释片的质量控制标准。

Abstract

Objective:To establish the quality standard of Yiganqing Sustained-released-tablet.Method:Hypericum perfortum L

the main ingredient in Yiganqing Sustained-released-tablet was identified by TLC.The content of hypericin in the tablet was determined by using HPLC.The column was Phenomenex Luna C18 column（4.6 mm×250 mm

5 μm）.The mobile phase was acetonitrile-0.025 mol·L-1 KH2PO4 solution（85:15）

and the detection wavelength was at 588 nm.Result:The TLC spots were clear and the separation degree was good.Hypericin was linear in the range of 0.076～0.76（r=0.999 9）.The average recovery was 98.66% and RSD was 2.51%.Conclusion:The results indicate that the method is simple

feasible and repeatable and can be used for quality control of Yiganqing Sustained-released-tablet.

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Related Author

WANG Xing

ZHANG Wei-guo

LI Ying

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WANG Ping

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Related Institution

Taiyuan Institute for Food and Drug Control,Taiyan

Shanxi Pharmaceutical Occupational College,Taiyan

Shanxi Shuangren Pharmaceutical Co.Ltd

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Guiyang College of Traditional Chinese Medicine

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