Effect of Tangzhiqing on Glycolipin Metabolism and Hepatic Histopathology in Rabbits with Hyperlipoidemia

LIU Zhan-biao; LI Yu-hong; ZHANG Shao-zhuo; SHI Yong-mei; ZHANG De-qin

doi:10.13422/j.cnki.syfjx.2011.15.052

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Effect of Tangzhiqing on Glycolipin Metabolism and Hepatic Histopathology in Rabbits with Hyperlipoidemia

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- Effect of Tangzhiqing on Glycolipin Metabolism and Hepatic Histopathology in Rabbits with Hyperlipoidemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 135-138(2011)
- 作者机构：
  
  天津中医药大学中医药研究院天津市中药药理学重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.052
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]柳占彪,李玉红,张少卓,师咏梅,张德芹.糖脂清对高脂血症家兔糖脂代谢及肝组织的影响[J].中国实验方剂学杂志,2011,17(15):135-138.

LIU Zhan-biao, LI Yu-hong, ZHANG Shao-zhuo, et al. Effect of Tangzhiqing on Glycolipin Metabolism and Hepatic Histopathology in Rabbits with Hyperlipoidemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 135-138.
[1]柳占彪,李玉红,张少卓,师咏梅,张德芹.糖脂清对高脂血症家兔糖脂代谢及肝组织的影响[J].中国实验方剂学杂志,2011,17(15):135-138. DOI： 10.13422/j.cnki.syfjx.2011.15.052.

LIU Zhan-biao, LI Yu-hong, ZHANG Shao-zhuo, et al. Effect of Tangzhiqing on Glycolipin Metabolism and Hepatic Histopathology in Rabbits with Hyperlipoidemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 135-138. DOI： 10.13422/j.cnki.syfjx.2011.15.052.

摘要

目的:观察糖脂清（TZQ）对高脂血症家兔糖脂代谢及肝组织的影响。方法:采用高脂饲料喂养建立高脂血症家兔模型

用TZQ以生药3.2

1.6

0.8 g.kg-1剂量

ig连续治疗30 d

测定血清总胆固醇（TC）、游离脂肪酸（FFA）、葡萄糖（Glu）及肝组织甘油三酯（TG）、糖原含量

观察肝脏组织病理形态变化。结果:糖脂清可降低高脂血症模型兔血清TC

FFA

Glu的含量（P<0.01

P<0.05）;减少肝组织TG和糖原的蓄积（P<0.01

P<0.05）;减轻肝组织的脂肪变性（P<0.01）。结论:糖脂清具有调节机体TC

FFA

Glu的代谢

减少肝组织TG和糖原的蓄积以及保护肝损伤的作用。

Abstract

Objective:To observe the effect of Tangzhiqing（TZQ） on glycolipin metabolism and hepatic histopathology in rabbits with hyperlipoidemia.Method:Rabbit model of hyperlipoidemia was established by feeding high lipid diet.The treatment of TZQ was applied by intragastric administration at dosage of 3.2

1.6

0.8 g·kg-1 respectively for 30 days.The serum content of total cholesterol（TC）

free fatty acid（FFA）

glucose（Glu） and the accumulation of liver triglyeride（TG） and glucogen were determined and the histopathological changes in liver were observed.Result:The serumal content of TC

FFA.Glu and the accumulation of liver TG and glucogen were reduced（P<0.01

P<0.05）

fatty degeneration of the liver were lightened（by rank sum test

P<0.01）in treated group of TZQ.Conclusion:TZQ can regulate the metabolic process of TC

FFA

Glu and decrease the accumulation of liver TG and glucogen

meanwhile has protective effect on hepatic injury in rabbits with hyperlipoidemia.

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Related Author

ZHANG De-qin

SHI Yong-mei

ZHANG Shao-zhuo

LI Yu-hong

LIU Zhan-biao

YANG Yue

Yang Qing

LIANG Ai-hua

Related Institution

Research Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine

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