Pharmacodynamical Investigation on Qinyu Burn Liquid for Treatment of Burn and Scald Healing

ZHANG Han1; YANG Qiao-li2; LI Yin3; LI Wei-qiang1; LIU Xun3

doi:10.13422/j.cnki.syfjx.2011.15.056

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Pharmacodynamical Investigation on Qinyu Burn Liquid for Treatment of Burn and Scald Healing

更新时间：2024-09-23

- Pharmacodynamical Investigation on Qinyu Burn Liquid for Treatment of Burn and Scald Healing
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 152-156(2011)
- 作者机构：
  
  1. 中国人民解放军69220部队医院
  2. 新疆维吾尔自治区药物研究所
  3. 新疆石河子大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.056
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]张晗,杨巧丽,李寅,李维强,刘循.芩榆烧伤液治疗烧烫伤的主要药效学研究[J].中国实验方剂学杂志,2011,17(15):152-156.

ZHANG Han1, YANG Qiao-li2, LI Yin3, et al. Pharmacodynamical Investigation on Qinyu Burn Liquid for Treatment of Burn and Scald Healing[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 152-156.
[1]张晗,杨巧丽,李寅,李维强,刘循.芩榆烧伤液治疗烧烫伤的主要药效学研究[J].中国实验方剂学杂志,2011,17(15):152-156. DOI： 10.13422/j.cnki.syfjx.2011.15.056.

ZHANG Han1, YANG Qiao-li2, LI Yin3, et al. Pharmacodynamical Investigation on Qinyu Burn Liquid for Treatment of Burn and Scald Healing[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 152-156. DOI： 10.13422/j.cnki.syfjx.2011.15.056.

摘要

目的:探讨芩榆烧伤液对烧烫伤的治疗作用。方法:采用大鼠深Ⅱ度烫伤模型进行烫伤实验

采用二甲苯致小鼠皮肤毛细血管通透性增高法和二甲苯致小鼠耳肿胀法进行抗炎实验

采用醋酸扭体法和小鼠热板法进行镇痛实验

采用肉汤稀释法测定芩榆烧伤液的最低抑菌浓度（MIC）、最低杀菌浓度（MBC）

对芩榆烧伤液进行烧烫伤、抗炎、镇痛、体外抑菌的实验。结果:芩榆烧伤液2个剂量（按生药量计0.25 g

0.50 g.mL-1

0.18 mL/次

每日喷2～3次）对大鼠深Ⅱ度烫伤创面愈合有较好的促进作用

芩榆烧伤液2个剂量（每只20μL×4次

每次间隔30～60 min）对二甲苯致小鼠皮肤毛细血管通透性增高和小鼠耳肿胀均有显著的抑制作用

对醋酸致小鼠扭体和小鼠热板致痛有显著的抑制作用

对金黄色葡萄球菌、绿脓杆菌和大肠杆菌的MIC分别为1.95

7.80

15.60 g.L-1

MBC分别为7.80

15.60

31.25 g.L-1。结论:芩榆烧伤液具有促进大鼠深Ⅱ度烫伤模型创面愈合、镇痛、抗炎作用

在体外对金黄色葡萄球菌、绿脓杆菌和大肠杆菌均有一定的抑菌作用。

Abstract

Objective:To investigate effect of Qinyu Burn Liquid（QY） for treatment of burn and scald healing.Method:The burn and scald healing effect of the QY was studied with the scald model of deep Ⅱ degree in rats.Anti-inflammatory effect of the QY was studied with the model of mouse with increase in skinny capillary permeability and the ear swelling induced by xylol in mouse.And

analgesic effect of QY was studied with mouse writhing response and hot plate test.The minimal inhibitory concentration（MIC） and minimal bactericidal concentration（MBC） of QY were determinand by broth dilution method.Result:QY of two doses（crude drugs 0.25 g

0.50 g·mL-1

0.18 mL/times

spray 2 to 3 times a day） had promoting role on rat burn wound healing deepⅡ.QY of two doses（each 20 μL × 4 times

each times interval of 30-60 min） could also obviously inhibit the increase of skin capillaries permeability and swelling of ear in mice induced by xylene

could significantly inhibit twisting caused by acetic acid and pain induced by hot plate in mice

and MIC were respectively 1.95

7.80

15.60 g·L-1 and the MBC were 7.80

15.60

31.25 g·L-1 to Staphylococcus aureus

Pseudomonas aeruginosa and Escherchia coli（E.coli）.Conclusion:On one hand the wound heal time of QY for rats with Ⅱ degree deep scald is superior to that of the model group.On the other hand

QY also has significant analgesic

anti-inflammatory and effect on S.aureus

P.aeruginosa and E.coli

especially S.aureus.

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Related Author

ZHANG Han

YANG Qiao-li

LI Yin

LI Wei-qiang

LIU Xun

WANG Qiu-ju1

LV Juan2

SHENG Li3

Related Institution

Cangzhou Medical College

Chengde Jingfukang Pharmaceutical Group Co.,Ltd

Institute of Chinese Materia Medica,Chengde Medical College

Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine

Department of New drug R&D in Guangzhou University of Traditional Chinese Medicine

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