Objective:To analysis pharmacodynamic contributed values of composition and pharmacodynamic simulation of compound Hugu capsules（HG）.Method:Ten components of HG were divided into 13 groups（group 13 for negative control group） by orthogonal simulation method

the drug serum was gotten by the serum pharmacological experiments and CCK-8 method was adopted to detect osteoblast（Ob） proliferation.Pharmacodynamic contributed values and pharmacodynamic simulation of compound were analysis by DAS3.0 software.Result:The proliferation of Ob as a index

a sequence of pharmacodynamic contributed values were found by orthogonal simulation method:Epimedii Folium>Drynariae Rhizoma>Morindae Officinalis Radix>Dioscoreae Rhizoma>Testudinis Carapax et Plastrum>Angelica Sinensis Radix>Rehmanniae Radix Praeparata>Dipsaci Radix>Eucommiae Cortex>Polygoni Multiflori Radix Praeparata Multiflorum F.With Ob proliferation as the index

and the results of pharmacodynamic simulation of compound showed that 27 compounds were better than the negative control group

and the original compound is the best in effect

the other four compounds are close to the original compound.Conclusion:Orthogonal simulation method is a method to analyze the Chinese herbal compound.This approach can determine pharmacodynamic contributed values of composition

and pharmacodynamic simulation of compound for HG.The method can provide a lot of information for studying Chinese herbal compound

and is benefit for developing new drug.