LV Li-xun1, YAO Rong-mei2, MA Hui-xia2, et al. Protective Effect of Kangdu Buxin Capsule on Chronic Myocardium Injury Induced by Adriamycin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 166-168.
LV Li-xun1, YAO Rong-mei2, MA Hui-xia2, et al. Protective Effect of Kangdu Buxin Capsule on Chronic Myocardium Injury Induced by Adriamycin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 166-168. DOI: 10.13422/j.cnki.syfjx.2011.15.059.
Protective Effect of Kangdu Buxin Capsule on Chronic Myocardium Injury Induced by Adriamycin in Rats
Objective:To investigate the protective effect of Kangdu Buxin Capsule on chronic injury and cardiotoxicity induced by adriamycin(ADM) in rats.Method:Male SD rats were randomly divided into six groups.Besides the control group
each group were injected with adriamycin(ADM
3 mg·kg-1 peritoneal injection) weekly for 6 weeks.Meanwhile
4 ADM-injected groups were received the treatment of Kangdu Buxin Capsule(0.4
0.8
1.6 g·kg-1) and Fufang Danshen tablet(0.45 g·kg-1)
respectively.Survivors were observed for hemodynamics changes.LVEF
FS and B-type Natriretic peptide(BNP)
the activities of GSH-Px and SOD
and MDA were measured and the hearts were removed for histological examination by light microscopy.Result:LVEF and FS were increased compared with the injury group
the activities of GSH-Px and SOD were higher
and the MDA lever was lower in therapy groups(P<0.05).Conclusion:Kangdu Buxin Capsule has protective effect and antioxidative effect on the cardiomyopathy of chronic heart disease induced by ADM in rats.
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Protective Effect and Mechanism of Aqueous Extract of Perillae Folium on Adriamycin-induced Oxidative Injury in HK-2 Cell
Mechanism of Huanglian Ejiao Tang on Prevention and Treatment of Myocardial Injury Induced by Anthracycline Chemotherapy Drugs
Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat
Related Author
LV Li-xun
YAO Rong-mei
MA Hui-xia
LI Jie
BAO Ju-tai
HE Xiao-mei
Li-yu WANG
Yan SHEN
Related Institution
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine
Affiliated Hospital of Nanjing University of Chinese Medicine
Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Prescription Department,Liaoning University of Traditional Chinese Medicine
Laboratory of Molecular Biology,Liaoning University of Traditional Chinese Medicine