Treatment of Chronic Pelvic Inflammation by Honghua Ruyi Pill in Rats

ZHANG Ying-shan1; LI Wen-ya1; ZHAO Hui2; ZHANG Qi2

doi:10.13422/j.cnki.syfjx.2011.15.064

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Treatment of Chronic Pelvic Inflammation by Honghua Ruyi Pill in Rats

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- Treatment of Chronic Pelvic Inflammation by Honghua Ruyi Pill in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 180-184(2011)
- 作者机构：
  
  1. 甘肃奇正藏药有限公司
  2. 首都医科大学中医药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.064
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]张樱山,李文雅,赵晖,张琪.红花如意丸治疗大鼠慢性盆腔炎的研究[J].中国实验方剂学杂志,2011,17(15):180-184.

ZHANG Ying-shan1, LI Wen-ya1, ZHAO Hui2, et al. Treatment of Chronic Pelvic Inflammation by Honghua Ruyi Pill in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 180-184.
[1]张樱山,李文雅,赵晖,张琪.红花如意丸治疗大鼠慢性盆腔炎的研究[J].中国实验方剂学杂志,2011,17(15):180-184. DOI： 10.13422/j.cnki.syfjx.2011.15.064.

ZHANG Ying-shan1, LI Wen-ya1, ZHAO Hui2, et al. Treatment of Chronic Pelvic Inflammation by Honghua Ruyi Pill in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 180-184. DOI： 10.13422/j.cnki.syfjx.2011.15.064.

摘要

目的:观察红花如意丸对慢性盆腔炎大鼠血清炎症细胞因子及子宫粘连相关免疫分子变化的影响

从免疫调节角度探讨红花如意丸治疗慢性盆腔炎的作用机制。方法:采用苯酚胶浆法制成大鼠慢性盆腔炎模型

随机分为正常组

模型组

红花如意丸低、中、高剂量组（0.156

0.469

1.407 g.kg-1）和桂枝茯苓胶囊（0.326 g.kg-1）组。造模10 d后

各治疗组ig给药20 d

观察子宫内膜的病理变化

酶联免疫吸附法检测各组大鼠血清肿瘤坏死因子α（TNF-α）、白细胞介素-2（IL-2）及子宫细胞间黏附分子（ICAM-1）的浓度。结果:红花如意丸能明显改善慢性盆腔炎大鼠子宫内膜病变程度

和正常组大鼠相比

模型大鼠血清IL-2明显降低（P<0.01）

TNF-α明显增高（P<0.01）;子宫ICAM-1含量明显增高（P<0.01）;经红花如意丸（1.407 g.kg-1）治疗后

大鼠血清IL-2较模型组明显增高

TNF-α明显降低（P<0.05）;子宫ICAM-1含量明显降低（P<0.05）。结论:红花如意丸可通过调节炎症细胞因子和子宫细胞间黏附分子的表达

治疗盆腔炎症

改善盆腔粘连。

Abstract

Objective:To probe the mechanism of Honghua Ruyi Pill for treatment of chronic pelvic inflammation through observing inflammatory cytokine in serum and immune molecules relative to metrosynizesis.Method:The animal model of chronic pelvic inflammation was replicated by injection of phenol mucilage.After 10 days

the model was replicated successfully.The rats were divided into six groups randomly

normal group

model group

lower dosage of Honghua Ruyi Pill（0.156 g·kg-1）

middle dosage of Honghua Ruyi Pill group（0.469 g·kg-1）

large dosage of of Honghua Ruyi Pill group（1.407 g·kg-1）and Cinnamon twig and Poria capsule group（0.326 g·kg-1）.After the rats were treated 20 days with corresponding medicine by intragastric administration

the pathological of endometrium was observed and the concentrations of tumor necrosis factor（TNF-α）

interleukin-2（IL-2）and intercellular adhesion molecular（ICAM-1） were examined in serum by enzyme linked immunosorbent assay（ELISA）.Result:Honghua Ruyi Pill could alleviate obviously the pathological damage of endometrium.In comparison with normal group

serum IL-2 in model group was significantly decreased（P<0.01）

and TNF-α was significantly elevated（P<0.01）;the concentration of ICAM-1 in uterus was significantly elevated（P<0.01）.After Honghua Ruyi Pill（1.407 g·kg-1）treatment

serum IL-2 was obviously elevated compared with the model group and TNF-α was obviously decreased（P<0.05）;the concentration of ICAM-1 in uterus was significantly decreased（P<0.05）.Conclusion:Honghua Ruyi Pill can alleviate the inflammation and adhesion of pelvic by regulating the expression of inflammatory cytokines in serum and intercellular adhesion molecules in endometrium.

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Related Institution

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Heilongjiang University of Chinese Medicine

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