Effects of Promoting Blood Circulation to Remove Blood Stasis of Herbs of Warm Channel and Explling Cold Pair in Shaofu Zhuyu Decoction

ZHOU Wei; SU Shu-lan; DUAN Jin-ao; TANG Yu-ping; QIAN Da-wei

doi:10.13422/j.cnki.syfjx.2011.15.066

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Effects of Promoting Blood Circulation to Remove Blood Stasis of Herbs of Warm Channel and Explling Cold Pair in Shaofu Zhuyu Decoction

更新时间：2024-09-23

- Effects of Promoting Blood Circulation to Remove Blood Stasis of Herbs of Warm Channel and Explling Cold Pair in Shaofu Zhuyu Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 188-192(2011)
- 作者机构：
  
  南京中医药大学江苏省方剂研究重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.066
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]周卫,宿树兰,段金廒,唐于平,钱大玮.温里药配伍对少腹逐瘀汤活血化瘀效应的影响[J].中国实验方剂学杂志,2011,17(15):188-192.

ZHOU Wei, SU Shu-lan, DUAN Jin-ao, et al. Effects of Promoting Blood Circulation to Remove Blood Stasis of Herbs of Warm Channel and Explling Cold Pair in Shaofu Zhuyu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 188-192.
[1]周卫,宿树兰,段金廒,唐于平,钱大玮.温里药配伍对少腹逐瘀汤活血化瘀效应的影响[J].中国实验方剂学杂志,2011,17(15):188-192. DOI： 10.13422/j.cnki.syfjx.2011.15.066.

ZHOU Wei, SU Shu-lan, DUAN Jin-ao, et al. Effects of Promoting Blood Circulation to Remove Blood Stasis of Herbs of Warm Channel and Explling Cold Pair in Shaofu Zhuyu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 188-192. DOI： 10.13422/j.cnki.syfjx.2011.15.066.

摘要

目的:评价温里药配伍对少腹逐瘀汤活血化瘀效应的影响。方法:采用体外实验观察不同提取物对二磷酸腺苷（ADP）诱导的血小板聚集作用及凝血酶时间（TT）法抗凝血作用的影响;采用大鼠急性血瘀模型评价少腹逐瘀汤、少腹逐瘀汤减小茴香-肉桂-干姜温里药组水提取物对血液流变性的影响。结果:少腹逐瘀汤能够明显抑制ADP诱导的血小板聚集

改善急性血瘀大鼠全血黏度（P<0.05）、血沉（P<0.05）;明显延长凝血酶时间（TT）、凝血酶原时间（PT）和部分活化凝血活酶时间（APTT）;而少腹逐瘀汤减小茴香等温里药物后仅在血浆黏度

PT指标显示显著性降低作用

而对血小板聚集作用、APTT;对纤维蛋白原未呈现明显影响。结论:温里药配伍后对少腹逐瘀汤活血化瘀效应具有一定的增强或协同作用。

Abstract

Objective:To evaluate the effects of Shaofu Zhuyu decoction

the decoction minus Wenli herb pair（herbs of warm channel and expelling cold） on hemorheological parameters in rat mode of acute blood stasis

and the influence on platelet aggregation and clotting time in vitro.Method:Rat model of acute blood stasis was used to evaluate the changes in hemorheological parameters

the function of blood coagulation and ovarian.The platelet aggregation was tested with Born’s method.The clotting parameters

including thrombin time（TT）

prothrombin time（PT） and activated partial thromboplastin time（APTT） in vitro

were established.Result:Shaofu Zhuyu decoction showed significant improvements in the hemorheological parameters

including whole blood viscosity and ESR（P<0.05） compared with the model of blood stasis.Meanwhile

the result of vitro assay showed that Shaofu Zhuyu decoction had significantly inhibitory effects on the platelet aggregation and prolonged clotting time for TT

PT and APTT.The effects of the decoction minus Wenli herb pair only showed effect of reducing plasma viscosity and extending TT and PT.Conclusion:Shaofu Zhuyu decoction could improve the indexes of hemorheology in rat model of blood stasis

and showed significant inhibitory effect on platelet aggregation and clotting time.Furthermore

Wenli herbs play an important role in the biological effect for the whole prescription.

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DUAN Jin-ao

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QIAN Da-wei

DUAN Jin-ao

HUA Yong-qing

LIU Pei

Related Institution

Jiangsu Key Laboratory for TCM formulae Reasearch,Nanjing University of Chinese Medicine

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