Effects of Kangdu Buxin Capsule on Immune Function in Immuno-suppressed Mice Induced with Cyclophosphamide

LV Li-xun1; YAO Yan-yan1; XU Jia1; MA Hui-xia2; BAO Ju-tai2; WANG Chun-yan1

doi:10.13422/j.cnki.syfjx.2011.15.067

您当前的位置：

首页 >

文章列表页 >

Effects of Kangdu Buxin Capsule on Immune Function in Immuno-suppressed Mice Induced with Cyclophosphamide

更新时间：2024-09-23

- Effects of Kangdu Buxin Capsule on Immune Function in Immuno-suppressed Mice Induced with Cyclophosphamide
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 193-195(2011)
- 作者机构：
  
  1. 河北联合大学药学院
  2. 河北联合大学中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.067
  CLC： R285.5
- Published：2011
- 稿件说明：
移动端阅览
[1]吕立勋,姚妍妍,许佳,马会霞,包巨太,王春宴.抗毒补心胶囊对环磷酰胺所致免疫抑制小鼠免疫功能的影响[J].中国实验方剂学杂志,2011,17(15):193-195.

LV Li-xun1, YAO Yan-yan1, XU Jia1, et al. Effects of Kangdu Buxin Capsule on Immune Function in Immuno-suppressed Mice Induced with Cyclophosphamide[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 193-195.
[1]吕立勋,姚妍妍,许佳,马会霞,包巨太,王春宴.抗毒补心胶囊对环磷酰胺所致免疫抑制小鼠免疫功能的影响[J].中国实验方剂学杂志,2011,17(15):193-195. DOI： 10.13422/j.cnki.syfjx.2011.15.067.

LV Li-xun1, YAO Yan-yan1, XU Jia1, et al. Effects of Kangdu Buxin Capsule on Immune Function in Immuno-suppressed Mice Induced with Cyclophosphamide[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 193-195. DOI： 10.13422/j.cnki.syfjx.2011.15.067.

摘要

目的:观察抗毒补心胶囊对环磷酰胺（CTX）所致免疫抑制小鼠免疫功能的影响。方法:注射CTX形成免疫低下小鼠模型

ig给予不同剂量的抗毒补心胶囊（4

8 g.kg-1）和阳性对照药香菇多糖片（10 g.kg-1）

以小鼠腹腔巨噬细胞的吞噬率和吞噬指数

外周血白细胞数及淋巴细胞转化率为观察指标。结果:ig给予抗毒补心胶囊4 g.kg-1后小鼠腹腔巨噬细胞的吞噬率和淋巴细胞转化率分别为（63.2±10.9）%和（47.33±6.18）%

ig给予8 g.kg-1的为（57.4±10.2）%和（43.07±6.23）%。抗毒补心胶囊对CTX致小鼠外周血白细胞减少有明显提升作用（P<0.05）

并能明显改善CTX所致小鼠腹腔巨噬细胞吞噬率和淋巴细胞转化率的降低（P<0.05）。结论:抗毒补心胶囊能增强CTX致免疫功能低下小鼠免疫功能

对免疫失衡机体具有保护作用。

Abstract

Objective:To observe the effects of Kangdu Buxin Capsule on immune function in immuno-suppressed（IS）mice induced with cyclophosphamide（CTX）.Method:The IS model was produced by intraperitoneal injection（ip）of CTX with a dose of 50 mg·kg-1in mice.The mice were randomly divided into normal control group

immunity deficiency model group

Kangdu Buxin Capsule treated group and positive control group respectively.The changes in the number of WBC

the phagocytosis activity of macrophage

and the proliferation of T lymphocyte in the spleen of mice were observed.Result:Compared with model group

Kangdu Buxin Capsule could increase the amount of the peripheral blood WBC（P<0.05）

the phagocytosis activity of macrophage

and the proliferation of T lymphocyte compared with the model group（P<0.05）.Conclusion:Kangdu Buxin Capsule has the effect of improving immune in immuno-suppressed mice induced with CTX

and has protective effect on the immune function of mice.

关键词

Keywords

references

Views

131

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Observation and Immunological Functions on Kangdu Buxin Capsule in Treatment of Viral Myocarditis

Regulation of Immune Function of Cyclophosphamide-induced Immunosuppressed Mice by Five Plant Polysaccharides： A Network Meta-analysis

Efficacy and Mechanism of Yishen Shengjing Prescription in Treatment of Oligoasthenospermia

Related Author

LV Li-xun

YAO Yan-yan

XU Jia

MA Hui-xia

BAO Ju-tai

WANG Chun-yan

LI Jie

WU Fan-wu

Related Institution

Shaanxi University of Chinese Medicine

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Beijing Research Institute of Chinese Medicine， Beijing University of Chinese Medicine

Key Laboratory of Famous Doctors and Famous Prescriptions of National Administration of TCM

School of Traditional Chinese Medicine （TCM）， Beijing University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰