MAO Zhang-zhi1, HUANG Bei2, YU Zhi-bin1. Effects of Naopingkang Granule on Learning and Memory in Rats with Transient Cerebral Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 195-198.
MAO Zhang-zhi1, HUANG Bei2, YU Zhi-bin1. Effects of Naopingkang Granule on Learning and Memory in Rats with Transient Cerebral Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 195-198. DOI: 10.13422/j.cnki.syfjx.2011.15.068.
Effects of Naopingkang Granule on Learning and Memory in Rats with Transient Cerebral Ischemia
Objective:To investigate the effects of Naopingkang granule on learning and memory in rats after transient cerebral ischemia.Method:Sixty Wistar rats(n=10/group) were randomly divided into six groups:the normal goup
the model group
the Donepezil group
high Naopingkang granule group(12 g·kg-1)
middle Naopingkang granule group(6 g·kg-1) and low Naopingkang granule group(3 g·kg-1).The treament groups were orally administered once per day separately
whereas the normal and model group were orally administered with distilled water.Ischemia model was made with 2-vessel-occlusion+hypotension
Morris water maze test and step-through passive avoidance test were employed to investigate the influences of Naopingkang granule on transient cerebral ischemia in rats.Result:In Morris water maze test
Naopingkang granule could significantly decrease escape latency time
swimming times in target quadrant was significantly recovered compared with that of model group(P<0.05);in Step-through passive avoidance test
the shorter step-through latency and much error number induced in transient cerebral ischemia was significantly reversed by Naopingkang granule treatment compared with that of model group(P<0.05);activety of AchE was inhibited compared with that of model group(P<0.05).Conclusion:Naopingkang granule could improve learning and memory.
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Related Author
MAO Zhang-zhi
HUANG Bei
YU Zhi-bin
LIU Huizhen
ZHANG Yini
CHEN Yumeng
XIAO Chunfeng
ZHANG Xuesong
Related Institution
School of Basic Medical Sciences, Hubei University of Chinese Medicine
Hubei Shizhen Laboratory
School of Pharmaceutics, Hubei University of Chinese Medicine
Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine
School of Traditional Chinese Medicine, Hubei University of Chinese Medicine