Effects of Guizhi Fuling Capsule on the Expression of MCP-1 and ICAM-1 mRNA of Ectopic Endometrium in Rats with Endometriotics

CAI Xue-ting1; HU Chun-ping2; HU Ting-ting3; WANG Zhi-gang2; CAO Peng2; WANG Min1

doi:10.13422/j.cnki.syfjx.2011.15.070

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Effects of Guizhi Fuling Capsule on the Expression of MCP-1 and ICAM-1 mRNA of Ectopic Endometrium in Rats with Endometriotics

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- Effects of Guizhi Fuling Capsule on the Expression of MCP-1 and ICAM-1 mRNA of Ectopic Endometrium in Rats with Endometriotics
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 202-205(2011)
- 作者机构：
  
  1. 中国药科大学
  2. 江苏省中医药研究院
  3. 南京市江北人民医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.070
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]蔡雪婷,胡春萍,胡婷婷,王志刚,曹鹏,王旻.桂枝茯苓胶囊对大鼠子宫内膜异位症异位内膜组织中MCP-1和ICAM-1 mRNA的影响[J].中国实验方剂学杂志,2011,17(15):202-205.

CAI Xue-ting1, HU Chun-ping2, HU Ting-ting3, et al. Effects of Guizhi Fuling Capsule on the Expression of MCP-1 and ICAM-1 mRNA of Ectopic Endometrium in Rats with Endometriotics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 202-205.
[1]蔡雪婷,胡春萍,胡婷婷,王志刚,曹鹏,王旻.桂枝茯苓胶囊对大鼠子宫内膜异位症异位内膜组织中MCP-1和ICAM-1 mRNA的影响[J].中国实验方剂学杂志,2011,17(15):202-205. DOI： 10.13422/j.cnki.syfjx.2011.15.070.

CAI Xue-ting1, HU Chun-ping2, HU Ting-ting3, et al. Effects of Guizhi Fuling Capsule on the Expression of MCP-1 and ICAM-1 mRNA of Ectopic Endometrium in Rats with Endometriotics[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 202-205. DOI： 10.13422/j.cnki.syfjx.2011.15.070.

摘要

目的:研究桂枝茯苓胶囊对大鼠子宫内膜异位症（EMs）异位内膜组织中单核细胞趋化蛋白-1（MCP-1）

细胞黏附分子-1（ICAM-1）在蛋白水平和转录水平的影响。方法:改进制作大鼠EMs动物模型

ig桂枝茯苓胶囊0.256

1.024 g.kg-1

28 d后取子宫内膜

采用免疫组化法检测内膜组织中MCP-1

ICAM-1的分布和表达;采用RT-PCR检测异位内膜组织中MCP-1

ICAM-1 mRNA的表达。结果:桂枝茯苓胶囊可降低大鼠子宫内膜异位内膜组织中MCP-1

ICAM-1的表达;高、低剂量组可使MCP-1

ICAM-1 mRNA水平显著下降（P<0.01）

两剂量之间无显著性差异。结论:桂枝茯苓胶囊可降低EMS异位内膜组织中MCP-1

ICAM-I的表达

降低其mRNA的表达。

Abstract

Objective:To study the effects of Guizhi Fuling Capsule on expression of monocyte chemoattractant protein-1（MCP-1） and inter-cellular adhesion molecule-1（ICAM-1） mRNA of ectopic endometrium in rats with endometriosis.Method:Endometriosis model of rat was created by self-transplant

and then administrated with Guizhi Fuling Capsule（0.256

1.024 g·kg-1） orally for 28 days.Expression and distribution of MCP-1 and ICAM-1 in ectopic endometrium were observed by immunohistochemistry.The mRNA expression of MCP-1

ICAM-1 were evaluated with RT-PCR.Result:The expression and distribution of MCP-1 and ICAM-1 were significantly decreased after treatment with Guizhi Fuling Capsule.Both dose showed similar effect without significant difference.Conclution:The distribution of MCP-1 and ICAM-1 in ectopic endometrium of endometriosis can be modified by Guizhi Fuling Capsule and the mRNA expression was decreased.

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