TANG Jing-shu1, PEI Qing-hua2. Neuroprotective Role of Panax Notoginseng Saponins on Cerebral Ischemia-reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 210-213.
TANG Jing-shu1, PEI Qing-hua2. Neuroprotective Role of Panax Notoginseng Saponins on Cerebral Ischemia-reperfusion Injury in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 210-213. DOI: 10.13422/j.cnki.syfjx.2011.15.072.
Neuroprotective Role of Panax Notoginseng Saponins on Cerebral Ischemia-reperfusion Injury in Rats
Objective:To investigate the effect of panax notoginseng saponins(PNS) on cerebral ischemia reperfusion injury in rats.Method:SD rats were divided into sham operation group
model group
PNS group.Model group and PNS group were established ischemia-reperfusion injury by using ligation of middle cerebral artery.PNS was given 15 min before ischemia and 6 h after ischemia
respectively
ip PNS 100 mg·kg-1 for rats in PNS group.Rats in model group and sham group were given at the same time ip with normal saline.The neurologic deficit score
brain infarction size and the levels of interleukin-1β(IL-1β)
tumor meerosis factor-α(TNF-α)
interleukin-6(IL-6)
interleukin-8(IL-8) and content of Evans blue in brain tissue were examined.Result:PNS could reduce infarct volume of cerebral ischemia-reperfusion injury in rats
reduce the extent of the damage in blood-brain barrier significantly.The levels of cytokines and content of Evans blue in PNS group were successively decreased as compared with those in model group(P<0.05).Conclusion:PNS has a significant brain protection on ischemia-reperfusion injury.PNS has significant effect of reducing the levels of cytokines
PNS can also reduce the permeability of blood-brain barrier.
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