Research of Carbon Nanotubes as Drug Carriers and Their Safety

WU Wei-kui1; ZHANG Hai-yan1; YANG Ming1; SONG Wei1; HE Ya1; LI Fang1

doi:10.13422/j.cnki.syfjx.2011.15.082

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Research of Carbon Nanotubes as Drug Carriers and Their Safety

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- Research of Carbon Nanotubes as Drug Carriers and Their Safety
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 15, Pages: 261-264(2011)
- 作者机构：
  
  1. 江西中医学院现代中药制剂教育部重点实验室
  2. 西南交通大学材料先进技术教育部重点实验室
  3. 成都中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.15.082
  CLC： R283
- Published：2011
- 稿件说明：
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[1]邬伟魁,张海燕,杨明,宋伟,贺娅,李芳.碳纳米管的载药及安全研究进展[J].中国实验方剂学杂志,2011,17(15):261-264.

WU Wei-kui1, ZHANG Hai-yan1, YANG Ming1, et al. Research of Carbon Nanotubes as Drug Carriers and Their Safety[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 261-264.
[1]邬伟魁,张海燕,杨明,宋伟,贺娅,李芳.碳纳米管的载药及安全研究进展[J].中国实验方剂学杂志,2011,17(15):261-264. DOI： 10.13422/j.cnki.syfjx.2011.15.082.

WU Wei-kui1, ZHANG Hai-yan1, YANG Ming1, et al. Research of Carbon Nanotubes as Drug Carriers and Their Safety[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 261-264. DOI： 10.13422/j.cnki.syfjx.2011.15.082.

摘要

对碳纳米管的载药进行文献整理和分析。查阅近8年来国内外相关文献39篇。研究发现

近年来

随着药学、生物学和材料学等多学科的交叉渗透发展

人们渐渐意识到新型载药材料的应用对药物的研究具有非常重要的促进作用。碳纳米管（carbon nanotubes

CNTs）具有独特的管状结构

可有效负载和递送药物

被巧妙地用于构建独具特色的药物传输系统。虽然CNTs的载药（特别是中药）研究国内外还少见报道

但实践证明

通过表面化学修饰等手段

制备溶解性好、低毒性的功能化CNTs作为药物载体

在抗肿瘤等领域具有很好的应用前景。作者概述了近年来CNTs的载药研究（如阿霉素、盐酸表柔比星、地塞米松、两性霉素B和中药有效成分异甘草素等）及生物安全研究（包括组织毒性研究和细胞毒性研究）进展

并对CNTs的中药载药应用作了展望

以期为更多安全、可控、有效的新型递药系统的研发及相关疾病的临床治疗提供参考。

Abstract

Study on carbon nanotubes（CNTs） as drug carriers and their safety were introduced in this review.Recent evidence suggests that with the cross development of biology and material science

researchers realized that applications of new drug carriers are crucial to the research of drugs.Due to their unique structure

CNTs can be used as drug carriers to build unique drug delivery system.In some rare cases

functionalized CNTs with good solubility and low toxicity show good perspective in used as drug carriers.However

research of CNTs be used as drug carriers（especially traditional Chinese medicine） is rarely reported at home and abroad.Study on CNTs as carriers（adriamycin

epirubicin hydrochloride

dexamethasone

amphotericin B and Isoliquiritigenin

etc.） and its toxicity（tissue toxicity and cell toxicity） is summarized.Emerging studies suggest that application of traditional Chinese medicine as drug carriers is attractive.We hope to provide reference for the development of safe

controlled and efficacious new drug carriers and clinical treatment of related diseases.

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