Preparation Technology of Total Flavonoids from Rhododendron capitatum Solid Dispersions

HUANG Zhi-long; LI Ling; HE Yu-xin

doi:10.13422/j.cnki.syfjx.2011.23.002

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Preparation Technology of Total Flavonoids from Rhododendron capitatum Solid Dispersions

更新时间：2024-09-23

- Preparation Technology of Total Flavonoids from Rhododendron capitatum Solid Dispersions
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 18-20(2011)
- 作者机构：
  
  西华大学生物工程学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.002
  CLC： TQ461
- Published：2011
- 稿件说明：
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[1]黄智龙,李玲,何宇新.小叶杜鹃总黄酮固体分散体制备工艺[J].中国实验方剂学杂志,2011,17(23):18-20.

HUANG Zhi-long, LI Ling, HE Yu-xin. Preparation Technology of Total Flavonoids from Rhododendron capitatum Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 18-20.
[1]黄智龙,李玲,何宇新.小叶杜鹃总黄酮固体分散体制备工艺[J].中国实验方剂学杂志,2011,17(23):18-20. DOI： 10.13422/j.cnki.syfjx.2011.23.002.

HUANG Zhi-long, LI Ling, HE Yu-xin. Preparation Technology of Total Flavonoids from Rhododendron capitatum Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 18-20. DOI： 10.13422/j.cnki.syfjx.2011.23.002.

摘要

目的:研究小叶杜鹃总黄酮-聚乙烯吡咯烷酮（PVP）固体分散体的最佳制备工艺。方法:选用L9（34）正交表设计试验

以固体分散体中总黄酮2 h累积溶出率作为评价指标

采用减压干燥法制备小叶杜鹃总黄酮-PVP固体分散体。结果:小叶杜鹃总黄酮固体分散体的最佳制备工艺为加6倍量载体

6倍量乙醇溶解

减压干燥2 h

干燥温度60℃。结论:小叶杜鹃总黄酮-PVP固体分散体对小叶杜鹃总黄酮有很好的增溶效果。

Abstract

Objective:To optimize preparation process for total flavonoids from Rhododendron Capitatum Maxim-PVP solid dispersions.Method:To establish experiment by orthogonal design test.Decompress dryness was used to prepare the solid dispersions

using dissolution in vitro to determine optimum technologic parameters.Result: Optimum process was established as following:6 times carriers

6 times alcohol as solvent

2 h as drying time

dryng temperature was 60 ℃.Conclusion:Total flavonoids of Rhododendron Capitatum Maxim solid dispersion prepared with PVP could increase dissolution of total flavonoids obviously.

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Related Institution

Second Affiliated Hospital of Zhengzhou University

Shanghai University of Traditional Chinese Medicine

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