DING Da-yong1, ZHANG Yan-yan2, GAO Fei2, et al. Optimization of Extraction and Preparation Technology of Shebai Fuyan Suppository[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 25-28.
DING Da-yong1, ZHANG Yan-yan2, GAO Fei2, et al. Optimization of Extraction and Preparation Technology of Shebai Fuyan Suppository[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 25-28. DOI: 10.13422/j.cnki.syfjx.2011.23.003.
Optimization of Extraction and Preparation Technology of Shebai Fuyan Suppository
Objective:To optimize extraction and preparation technology of Shebai Fuyan suppository.Method: Optimize extraction technology of Shebai Fuyan suppository by orthogonal design with extraction quantity of berberine and osthole as indexes to composite score.By examining results of mixed state of matrix and drug
mobility
appearance
hardness
melting time changes
dissolution and remaining sample observation in preparation process of suppository to determine it’s preparation technology.Result: Optimum extraction conditions were as follows:extracted 2 times with 6 folds of 85% ethanol for 2 h each time;Optimum preparation technology were select matrix PEG6000
PEG600 with proportion of 3∶7
the same amount of weight with concentrated liquid.Conclusion: This technology wss rational
could be used as basis for trial production of preparation.
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Related Author
DING Da-yong
ZHANG Yan-yan
GAO Fei
YAO Lin
YAO Lin
SUN Yan
WANG Wei-ming
DENG Dongjie
Related Institution
Key Laboratory of Chinese Medicine Resource and Compound Prescription, Hubei University of Chinese Medicine
Pharmacy Faculty, Hubei University of Chinese Medicine
Beijing University of Chinese Medicine
Henan Zhongjing's Prescription Healthy Aging Industry Engineering Research Center, Henan University of Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences