Optimal Extraction Technology of Schisandra chinensis Fruit by Central Composite Design/Response Surface Method

TIAN Zhen-kun; MA Ying-li; WU Lun; CHEN Juan; LIU Jia

doi:10.13422/j.cnki.syfjx.2011.23.004

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Optimal Extraction Technology of Schisandra chinensis Fruit by Central Composite Design/Response Surface Method

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- Optimal Extraction Technology of Schisandra chinensis Fruit by Central Composite Design/Response Surface Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 28-31(2011)
- 作者机构：
  
  黑龙江中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.004
  CLC： R284;TQ461
- Published：2011
- 稿件说明：
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[1]田振坤,马英丽,吴伦,陈娟,刘佳.星点设计-效应面法优化北五味子果实提取工艺[J].中国实验方剂学杂志,2011,17(23):28-31.

TIAN Zhen-kun, MA Ying-li, WU Lun, et al. Optimal Extraction Technology of Schisandra chinensis Fruit by Central Composite Design/Response Surface Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 28-31.
[1]田振坤,马英丽,吴伦,陈娟,刘佳.星点设计-效应面法优化北五味子果实提取工艺[J].中国实验方剂学杂志,2011,17(23):28-31. DOI： 10.13422/j.cnki.syfjx.2011.23.004.

TIAN Zhen-kun, MA Ying-li, WU Lun, et al. Optimal Extraction Technology of Schisandra chinensis Fruit by Central Composite Design/Response Surface Method[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 28-31. DOI： 10.13422/j.cnki.syfjx.2011.23.004.

摘要

目的:星点设计-效应面法优选北五味子果实的提取工艺。方法:以乙醇体积分数、提取时间、溶媒比为自变量

以北五味子总木脂素含量得率为因变量

通过对自变量各水平的多元线性回归及二项式拟合

用效应面法选取最佳工艺

并进行预测分析。结果:确定最优提取工艺为20倍量85%乙醇

提取3次

每次170 min

提取预测值与理论值偏差为0.19%

二项式拟合复相关系数r=0.994 2。结论:星点设计-效应面法优化的北五味子果实提取工艺

方法简单

精密度高

可预测性较优。

Abstract

Objective:To optimize extraction process of Schisandra chinensis fruit by central composite design/response surface method.Method: Independent variables were ethanol concentration

extraction time and solvent ratio

dependent variable was extraction rate of total saponins in S.chinensis.Linear or no-linear mathematic models were used to estimate relationship between independent and dependent variables.Response surface methodology was used to optimize extraction process

prediction was carried out through comparing observed and predicted values.Result: Optimal conditions of extraction process were as following:extracted 3 times with 85% ethanol for 170 min each time.The bias between observed and predicted values was 0.19%.Regression coefficients of binomial fitting complex model was as high as 0.994 2.Conclusion: This extraction process of S.chinensis fruit by central composite design/response surface methodology was simple

high precision

good predictability.

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Related Author

TIAN Zhen-kun

MA Ying-li

WU Lun

CHEN Juan

LIU Jia

HUANG Yuan-hong

WEI Tian-xi

ZHANG Fa-sheng

Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Medical School， Lijiang Culture and Tourism College

Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM），Ministry of Education，Jiangxi University of Chinese Medicine

Chengdu University of TCM

Medical School of Lijiang Culture and Tourism College

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