Purification Technology of Coumarin from Cortex Daphnes by Macroporous Resin

SHENG Hua-gang; ZHU Li-qiao; WANG Yuan-guo; LIN Gui-tao

doi:10.13422/j.cnki.syfjx.2011.23.018

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Purification Technology of Coumarin from Cortex Daphnes by Macroporous Resin

更新时间：2024-09-23

- Purification Technology of Coumarin from Cortex Daphnes by Macroporous Resin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 14-17(2011)
- 作者机构：
  
  山东中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.018
  CLC： R284
- Published：2011
- 稿件说明：
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[1]盛华刚,朱立俏,王远国,林桂涛.大孔树脂纯化祖师麻中香豆素类成分的工艺优选[J].中国实验方剂学杂志,2011,17(23):14-17.

SHENG Hua-gang, ZHU Li-qiao, WANG Yuan-guo, et al. Purification Technology of Coumarin from Cortex Daphnes by Macroporous Resin[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 14-17.
[1]盛华刚,朱立俏,王远国,林桂涛.大孔树脂纯化祖师麻中香豆素类成分的工艺优选[J].中国实验方剂学杂志,2011,17(23):14-17. DOI： 10.13422/j.cnki.syfjx.2011.23.018.

SHENG Hua-gang, ZHU Li-qiao, WANG Yuan-guo, et al. Purification Technology of Coumarin from Cortex Daphnes by Macroporous Resin[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 14-17. DOI： 10.13422/j.cnki.syfjx.2011.23.018.

摘要

目的:研究大孔树脂纯化祖师麻中香豆素类成分的工艺。方法:以祖师麻甲素、总香豆素为指标

考察了3种大孔树脂的吸附效果并系统研究大孔树脂对祖师麻中香豆素类成分的吸附性能和洗脱参数。结果:D-101大孔树脂对祖师麻甲素、总香豆素有较好的纯化性能

最佳上样工艺是药液质量浓度生药50 g.L-1

上柱流速2 BV.h-1

pH 3.0。上样后先用4 BV水洗脱

继以5 BV50%乙醇洗脱

洗脱液流速2 BV.h-1。结论:确定的大孔树脂纯化祖师麻中的香豆素类成分的工艺是合理的。

Abstract

Objective:To establish purification technology of coumarin from Cortex Daphnes.Method: Investigated adsorption capacity of 3 kinds of macroporous resin with daphnetin and coumarins as indexes

and adsorption characteristics and elutive ratio of coumarin from Cortex Daphnes were studied systematically.Result: D-101 resin had a better purification performance to daphnetin and coumarins.Optimum conditions were as follows:concentration of durg 50 g·L-1 in terms of raw material

adsorption speed was 2 BV·h-1

pH of sample for loading 3.0.After eluted with 4 BV of distilled water

5 BV 50% ethanol was used with desorption speed was 2 BV·h-1.Conclusion: This process of applying macroporous resin to purify coumarin in Cortex Daphnes was reasonable and feasible.

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