Observation of Effects of Tianshengyuan Oral Solution in Mice with Immune-Mediated Aplastic Anemia

LIU Ping1; QIN Xiao-tian3; ZHU Chuan-jiang1

doi:10.13422/j.cnki.syfjx.2011.23.035

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Observation of Effects of Tianshengyuan Oral Solution in Mice with Immune-Mediated Aplastic Anemia

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- Observation of Effects of Tianshengyuan Oral Solution in Mice with Immune-Mediated Aplastic Anemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 207-211(2011)
- 作者机构：
  
  1. 中国医学科学院北京协和医学院药物研究所
  2. 浙江中医药大学药学院
  3. 北京天雨义鸣生物科技有限公司
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.035
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]刘苹,秦晓天,朱传江.天升元口服液在免疫介导的再生障碍性贫血模型小鼠上的效应观察[J].中国实验方剂学杂志,2011,17(23):207-211.

LIU Ping1, QIN Xiao-tian3, ZHU Chuan-jiang1. Observation of Effects of Tianshengyuan Oral Solution in Mice with Immune-Mediated Aplastic Anemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 207-211.
[1]刘苹,秦晓天,朱传江.天升元口服液在免疫介导的再生障碍性贫血模型小鼠上的效应观察[J].中国实验方剂学杂志,2011,17(23):207-211. DOI： 10.13422/j.cnki.syfjx.2011.23.035.

LIU Ping1, QIN Xiao-tian3, ZHU Chuan-jiang1. Observation of Effects of Tianshengyuan Oral Solution in Mice with Immune-Mediated Aplastic Anemia[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 207-211. DOI： 10.13422/j.cnki.syfjx.2011.23.035.

摘要

目的:观察候选新中药天升元口服液对免疫介导的再生障碍性贫血（immune-mediated aplastic anemia

IAA）模型小鼠的效应。方法:建立IAA小鼠模型

给予天升元口服液14 d后

检测外周血白细胞（WBC）、红细胞（RBC）、血红蛋白（HGB）、红细胞比积（HCT）、血小板（PLT）、网织红细胞（RET）、股骨骨髓有核细胞（BMNC）和脾脏指数

并进行股骨和脾脏病理形态学观察。结果:模型对照组WBC

RBC

HGB

HCT

PLT

RET

BMNC和脾脏指数均较正常对照组显著下降（P<0.001）;而天升元口服液（12.4

24.8 g.kg-1.d-1）能显著升高模型小鼠WBC（升幅分别达150%和133.3%）

RBC（9.5%和37.1%）

HGB（12.9%和44.5%）

HCT（11.6%和28.4%）

PLT（94.8%和252.3%）

RET（115.4%和123.1%）

BMNC（71.1%和95.6%）和脾脏指数（18.7%和33.7%）

与模型组比较差异显著（P<0.05～0.001）。病理学检查显示天升元口服液明显增加骨髓造血细胞

降低脂肪细胞产生

减轻脾小体萎缩状态

促进脾小体髓外造血灶产生。结论:天升元口服液通过促进骨髓内外造血细胞增殖

改善造血功能

产生对IAA模型小鼠的治疗效应。

Abstract

Objective:To observe the effects of Tianshengyuan oral solution（TSY）

a new candidate Chinese medicine

in mice with immunologically mediated aplastic anemia（IAA）.Method: Mouse models with IAA were developed and given TSY by gavage for 14 days.Then peripheral WBC

RBC

HGB

HCT

PLT

reticulocyte（RET）

femoral bone marrow nucleus cell（BMNC）

spleen index

and pathological features of femoral bone marrow and spleen tissues were examined.Result: The values of WBC

RBC

HGB

HCT

PLT

RET

BMNC

and spleen index in the model group were remarkably lower than those in the normal group（P

0.001）.TSY（12.4

24.8 g·kg-1·d-1）could significantly increase the amount of WBC（at the ratio of 150.0% and 133.3%

respectively）

RBC（9.5% and 37.1%）

HGB（12.9% and 44.5%）

HCT（11.6% and 28.4%）

PLT（94.8% and 252.3%）

RET（115.4% and 123.1%）

BMNC（71.1% and 95.6%）and spleen index（18.7% and 33.7%）

compared with IAA model group（P

0.05

.001）.Furthermore

pathological examination for the femoral bone marrow and spleen tissues indicated that TSY could obviously increase in hematopoietic cells

decrease in fatty cells

alleviate the atrophy of the splenic corpuscles

and accelerate the growth of hematopoietic focuses in spleen.Conclusion: TSY could promote the proliferation of hematopoietic cells inside and outside bone marrow

improve the function of hematopoiesis

thus have a great potential for the treatment of mice with IAA.

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Related Author

LIU Ping

QIN Xiao-tian

ZHU Chuan-jiang

SHI Mei-jun

SUN Junyang

HE Dongchu

ZHANG Yaoyin

ZHANG Chaochang

Related Institution

Central Theater General Hospital of PLA

Hubei University of Chinese Medicine

Dongfang Hospital， Beijing University of Chinese Medicine

Graduate School of Beijing University of Chinese Medicine

Graduate School of China Academy of Chinese Medical Sciences

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