LIU De-wen1, ZHANG Yi1, WANG Jin-yu1, et al. Tissue Distribution and Excretion of 8-Acetylharpagide in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 220-222.
LIU De-wen1, ZHANG Yi1, WANG Jin-yu1, et al. Tissue Distribution and Excretion of 8-Acetylharpagide in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 220-222. DOI: 10.13422/j.cnki.syfjx.2011.23.038.
Tissue Distribution and Excretion of 8-Acetylharpagide in Rats
Objective:To study on tissue distribution and metabolism of 8-acetylharpagide in rats.Method: The content of 8-acetylharpagide in tissue and excreta at different time points after tail vein injection were determined by HPLC
then analyzed distribution of 8-acetylharpagide.Result:After injected
the content of 8-acetylharpagide in heart
spleen
lung
kidney and uterus reached peak in 10 min
the highest concentration was in kidney;Concentration of 8-acetylharpagide in liver reached peak in 30 min
the content of 8-acetylharpagide in liver
lung and kidney reduced to a lower level in 60 min
it could not be detected in heart
spleen and uterus;after injected
8-acetylharpagide was discharged mostly through urine
less excreted by stool.Conclusion: By injection
8-acetylharpagide excreted in prototype drugs mainly.
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Related Author
LIU De-wen
Zhang Yi
WANG Jin-yu
LI De-feng
YOU Yun
CAO Lan
WANG Fang
FENG Wei-hong
Related Institution
School of Life Sciences,Beijing University of Chinese Medicine
Third Grade Laboratory of Traditional Chinese Medicine(TCM) Preparations,National Administration of TCM,Shuguang Hospital Affiliated to Shanghai University of TCM
Affiliated Hospital of Nanjing University of Chinese Medicine