Study on Pharmaceutical Excipients of Nasal Preparation

WU Wei-kui1; ZHANG Hai-yan1; SONG Wei1; HE Ya1; LI Fang1; YANG Ming1

doi:10.13422/j.cnki.syfjx.2011.23.041

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Study on Pharmaceutical Excipients of Nasal Preparation

更新时间：2024-09-23

- Study on Pharmaceutical Excipients of Nasal Preparation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 254-258(2011)
- 作者机构：
  
  1. 江西中医学院现代中药制剂教育部重点实验室
  2. 西南交通大学材料先进技术教育部重点实验室
  3. 成都中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.041
  CLC： R283
- Published：2011
- 稿件说明：
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[1]邬伟魁,张海燕,宋伟,贺娅,李芳,杨明.鼻用制剂药用辅料研究[J].中国实验方剂学杂志,2011,17(23):254-258.

WU Wei-kui1, ZHANG Hai-yan1, SONG Wei1, et al. Study on Pharmaceutical Excipients of Nasal Preparation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 254-258.
[1]邬伟魁,张海燕,宋伟,贺娅,李芳,杨明.鼻用制剂药用辅料研究[J].中国实验方剂学杂志,2011,17(23):254-258. DOI： 10.13422/j.cnki.syfjx.2011.23.041.

WU Wei-kui1, ZHANG Hai-yan1, SONG Wei1, et al. Study on Pharmaceutical Excipients of Nasal Preparation[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 254-258. DOI： 10.13422/j.cnki.syfjx.2011.23.041.

摘要

对鼻用制剂药用辅料研究进行文献整理和分析。经检索、筛选得国内外文献32篇

主要综述了常用鼻用辅料如吸收促进剂（环糊精及其衍生物、表面活性剂、冰片和月桂氮酮等）、生物黏附剂（如壳聚糖）、防腐剂等的基本物化性质、功能性和安全性研究。分析表明

基于当前国内鼻用制剂药用辅料生产、包装、质量、贮存、使用等环节的现状

业内人士日益认识到鼻用辅料质量及合理应用与鼻用制剂质量的紧密关系

但我国辅料生产和研究仍很大程度落后于西方发达国家

加强产学研有机结合

促进新辅料、新技术和新型载药系统的研发

将有利于国产鼻用制剂的研发和临床应用及其药用辅料的质量标准提高。

Abstract

Literatures about study on pharmaceutical excipients of nasal preparations have been analyzed.Thirty-two literatures at home and abroad were sieved.This paper reviews basic physicochemical properties

functionality and security of common nasal excipients（absorption enhancer

bio-adhesion

preservative）.It was demonstrated that based on manufacture

package

quality

storage and application of domestic nasal excipients

researchers have recognized the closing relation between nasal excipients and nasal preparation.To push forward the development and clinic application of nasal preparation

and quality standard of pharmaceutical excipient

strengthen organic combination of production

study and research

promote new excipients

new technology and new drug deliver system is important.

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