Study on the Content Change of Neomangiferin in the Drug Couple about Different Compatibility Proportion in Anemarrhenae Rhizoma and Gypsum Fibrosum

YANG Su-de1; SUN Hong-sheng2; FU Chun-sheng2

doi:10.13422/j.cnki.syfjx.2011.23.045

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Study on the Content Change of Neomangiferin in the Drug Couple about Different Compatibility Proportion in Anemarrhenae Rhizoma and Gypsum Fibrosum

更新时间：2024-09-23

- Study on the Content Change of Neomangiferin in the Drug Couple about Different Compatibility Proportion in Anemarrhenae Rhizoma and Gypsum Fibrosum
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 48-50(2011)
- 作者机构：
  
  1. 山东中医药大学
  2. 山东中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.045
  CLC： R284.1
- Published：2011
- 稿件说明：
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[1]杨素德,孙洪胜,傅春升.石膏-知母药对不同配伍比例中新芒果苷含量变化研究[J].中国实验方剂学杂志,2011,17(23):48-50.

YANG Su-de1, SUN Hong-sheng2, FU Chun-sheng2. Study on the Content Change of Neomangiferin in the Drug Couple about Different Compatibility Proportion in Anemarrhenae Rhizoma and Gypsum Fibrosum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 48-50.
[1]杨素德,孙洪胜,傅春升.石膏-知母药对不同配伍比例中新芒果苷含量变化研究[J].中国实验方剂学杂志,2011,17(23):48-50. DOI： 10.13422/j.cnki.syfjx.2011.23.045.

YANG Su-de1, SUN Hong-sheng2, FU Chun-sheng2. Study on the Content Change of Neomangiferin in the Drug Couple about Different Compatibility Proportion in Anemarrhenae Rhizoma and Gypsum Fibrosum[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 48-50. DOI： 10.13422/j.cnki.syfjx.2011.23.045.

摘要

目的:建立测定中药药对石膏-知母中新芒果苷的方法

探索不同配伍比例中该成分的变化规律。方法:用HPLC法测定新芒果苷含量

色谱条件Waters C18柱（4.6 mm×250 mm

5μm）;乙腈-0.2%醋酸水（15∶85）为流动相;流速为1.0 mL.min-1;检测波长为258.0 nm。结果:中药药对石膏-知母在配伍时

新芒果苷含量变化规律随配伍比例增加其含量先增大后减小

在3∶1时含量最大。结论:方法简便、准确、重复性好

可用于中药药对石膏-知母中新芒果苷测定

并印证了"中医不传之秘在于剂量"之说

为进一步研究指明了方向。

Abstract

Objective:To establish a method for the determination about the contents of neomangiferin in the drug couple about Anemarrhenae Rhizoma and Gypsum Fibrosum

To explore the variation of the composition in the compatibility of different proportions.Method: High performance liquid chromatography（HPLC） was used to determine the changes in different groups of Anemarrhenae Rhizoma compatible with Gypsum Fibrosum.Separation was performed on C18（4.6 mm×250 mm

5 μm） analytical column.The mobile phase was ACN-0.2% CH3COOH（15∶85）.flow rate was 1.0 mL·min-1.detection wavelength was at 258.0 nm.Result:The contents of neomangiferin changed when Gypsum Fibrosum was added into the groups of Anemarrhenae Rhizoma.Some of ratios of Gypsum Fibrosum can increase the content of neomangiferin at first then decrease when the protortion was 3∶1（Gypsum Fibrosum-Anemarrhenae Rhizoma）.Conclusion:This method is simple

accurate and good repeatability.It can be used for the determination about the contents of neomangiferin in the drug couple about Anemarrhenae Rhizoma and Gypsum Fibrosum.The reseach proved the theory that ’the secret of Chinese medicine is due to the dose’

which points out the direction for further research.

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Related Author

YANG Su-de

SUN Hong-sheng

FU Chun-sheng

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Related Institution

Department of Pharmacy,Hebei North University

Pharmaceutical Department of North China Coal Medical University

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