Determination of Catalpol and Cinnamicacid in Yanbianning Granule by HPLC

BAI Zi-jing; QI Guang-cai; LIU Zhen-ye; LIU Fu-mei

doi:10.13422/j.cnki.syfjx.2011.23.053

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Determination of Catalpol and Cinnamicacid in Yanbianning Granule by HPLC

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- Determination of Catalpol and Cinnamicacid in Yanbianning Granule by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 71-73(2011)
- 作者机构：
  
  延安大学化学与化工学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.053
  CLC： R286
- Published：2011
- 稿件说明：
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[1]白梓静,齐广才,刘珍叶,刘福梅.HPLC测定咽扁宁冲剂中梓醇和肉桂酸含量[J].中国实验方剂学杂志,2011,17(23):71-73.

BAI Zi-jing, QI Guang-cai, LIU Zhen-ye, et al. Determination of Catalpol and Cinnamicacid in Yanbianning Granule by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 71-73.
[1]白梓静,齐广才,刘珍叶,刘福梅.HPLC测定咽扁宁冲剂中梓醇和肉桂酸含量[J].中国实验方剂学杂志,2011,17(23):71-73. DOI： 10.13422/j.cnki.syfjx.2011.23.053.

BAI Zi-jing, QI Guang-cai, LIU Zhen-ye, et al. Determination of Catalpol and Cinnamicacid in Yanbianning Granule by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 71-73. DOI： 10.13422/j.cnki.syfjx.2011.23.053.

摘要

目的:建立咽扁宁冲剂中梓醇和肉桂酸的含量测定方法。方法:采用Agilent ZORBAX SB-C18（4.6 mm×250 mm

5μm）

梓醇:流动相为水-甲醇-乙腈（95∶4∶1）

波长212 nm

流速1.0 mL.min-1;肉桂酸:流动相为甲醇-1%冰乙酸溶液（50∶50）

波长278 nm

流速1.2 mL.min-1。结果:梓醇和肉桂酸分别在3.36～168

0.156～104 mg.L-1呈良好的线性关系。平均回收率分别为梓醇101.59%

RSD 1.36%（n=5）;肉桂酸101.28%

RSD 1.28%（n=5）。结论:此方法简便

准确

重复性好

可用于咽扁宁冲剂的质量控制和评价。

Abstract

Objective:To establish the method for determination of catalpol and cinnamicacid in Yanbianning granule.Method: Catalpol and cinnamicacid were determined by HPLC on C18-column at 212 nm and 278 nm

with water-methanol-acetonitrile（95∶4∶1） and methanol-1% ice acetic（50∶50） as mobile phase

the flow rate were 1.0 mL·min-1 and 1.2 mL·min-1

respectively.Result:Under each condition

The calibration curves of catalpol and cinnamicacid were linear in the ranges of 3.36-168

0.156-104 mg·L-1

respectively.And the each average recoveries of the method were 101.59% for catalpol（RSD 1.36%

n=5）

101.28.% for cinnamicacid（RSD 1.28%

n=5）.Conclusion:The method is simple

accurate and repeatable

it can be used for quality control of Yanbianning granule.

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