The Effect of Sini Decoction on Intestinal Mucosa Injury and Translocation of Bacteria Induced by Hemorrhagic Shock

CHEN Lan-ying1; WU Gang1; CHEN Zhuo1; DONG Xin-xin2; DUAN Meng1; WANG Chang-qin1; CHEN Jin-long1; LIU Hong-ning1

doi:10.13422/j.cnki.syfjx.2011.23.058

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The Effect of Sini Decoction on Intestinal Mucosa Injury and Translocation of Bacteria Induced by Hemorrhagic Shock

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- The Effect of Sini Decoction on Intestinal Mucosa Injury and Translocation of Bacteria Induced by Hemorrhagic Shock
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 121-124(2011)
- 作者机构：
  
  1. 江西中医学院
  2. 中药固体制剂制造技术国家工程研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.058
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]陈兰英,吴刚,陈卓,董鑫鑫,段萌,王昌芹,陈金龙,刘红宁.四逆汤抗失血性休克大鼠肠黏膜损伤及菌群移位药效研究[J].中国实验方剂学杂志,2011,17(23):121-124.

CHEN Lan-ying1, WU Gang1, CHEN Zhuo1, et al. The Effect of Sini Decoction on Intestinal Mucosa Injury and Translocation of Bacteria Induced by Hemorrhagic Shock[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 121-124.
[1]陈兰英,吴刚,陈卓,董鑫鑫,段萌,王昌芹,陈金龙,刘红宁.四逆汤抗失血性休克大鼠肠黏膜损伤及菌群移位药效研究[J].中国实验方剂学杂志,2011,17(23):121-124. DOI： 10.13422/j.cnki.syfjx.2011.23.058.

CHEN Lan-ying1, WU Gang1, CHEN Zhuo1, et al. The Effect of Sini Decoction on Intestinal Mucosa Injury and Translocation of Bacteria Induced by Hemorrhagic Shock[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 121-124. DOI： 10.13422/j.cnki.syfjx.2011.23.058.

摘要

目的:研究四逆汤对失血性休克大鼠肠黏膜损伤及肠道菌移位的影响。方法:动物分为空白组、失血性休克组、四逆汤高、低剂量组（按生药量计4.8

2.4 g.kg-1）。通过定血量放血建立大鼠失血性休克模型

观察复苏3 h后肠黏膜损伤程度

并取肝、脾、肾和肠系膜淋巴结进行细菌培养

测定肝门静脉血浆内毒素、动脉血浆D-乳酸（D-Lac）含量。并通过血浆肿瘤坏死因子-α（TNF-α）、总一氧化氮合酶（t-NOS）的测定进行作用机制的探讨。结果:四逆汤与模型组比较

肠黏膜病理学改变得到显著改善

细菌培养计数、内毒素及D-Lac含量显著减少。血浆t-NOS显著减少

TNF-α有降低趋势

四逆汤药效作用呈剂量依赖性增强。结论:四逆汤能够抑制肠道菌移位

减轻肠黏膜损伤。作用机制可能与抑制t-NOS

TNF-α有关。

Abstract

Objective:To investigate the effect of Sini decoction（SND） on the intestinal mucosal injury and intestinal bacterial translocation induced by hemorrhagic shock.Method: The animals were randomly divided into normal group

shock model group

SND high dose group

SND low dose group.The shock model was induced by hemorrhaging for one hour and then resuscitating with shedding blood and same-volume Ringer lactate solution.The morphological changes in ileum mucosa were observed under light microscope.The intestinal bacteria in the liver

spleen

kidney and mesenteric lymph nodes was counted after 24 h culture.The level of endotoxin and D-lactate（D-Lac） in plasma was determined after 3 h resuscitation.Result: Compared with the model group

the intestinal pathology in SND groups significantly improved

the number of translocated intestinal bacteria and the level of endotoxin and D-Lac in SND groups were significantly reduced.The nitric oxide synthase（t-NOS） was significantly reduced and tumor necrosis factor-α（TNF-α） tended to decrease in SND group.The efficacy of SND was in a dose dependent manner.Conclusion: The SND can reduce intestinal injury and inhibit the translocation of intestinal bacteria.The mechanism may be related to inhibition of t-NOS

TNF-α.

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Related Institution

Hunan University of traditional Chinese medicine

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