Effect of Ten Traditional Chinese Medicine on Planktonic and Biofilm Candida Albicans in vitro

GONG Yu-jing; LIU Hong; FENG Shu-yi; ZHOU Yan-hua; SUN Ming-jie

doi:10.13422/j.cnki.syfjx.2011.23.060

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Effect of Ten Traditional Chinese Medicine on Planktonic and Biofilm Candida Albicans in vitro

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- Effect of Ten Traditional Chinese Medicine on Planktonic and Biofilm Candida Albicans in vitro
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 129-132(2011)
- 作者机构：
  
  中国中医科学院医学实验中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.060
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]宫毓静,刘红,冯淑怡,周艳华,孙明杰.牡丹皮等10种中药对白色念珠菌浮游菌和生物膜作用的研究[J].中国实验方剂学杂志,2011,17(23):129-132.

GONG Yu-jing, LIU Hong, FENG Shu-yi, et al. Effect of Ten Traditional Chinese Medicine on Planktonic and Biofilm Candida Albicans in vitro[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 129-132.
[1]宫毓静,刘红,冯淑怡,周艳华,孙明杰.牡丹皮等10种中药对白色念珠菌浮游菌和生物膜作用的研究[J].中国实验方剂学杂志,2011,17(23):129-132. DOI： 10.13422/j.cnki.syfjx.2011.23.060.

GONG Yu-jing, LIU Hong, FENG Shu-yi, et al. Effect of Ten Traditional Chinese Medicine on Planktonic and Biofilm Candida Albicans in vitro[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 129-132. DOI： 10.13422/j.cnki.syfjx.2011.23.060.

摘要

目的:观察牡丹皮等10种中药和土槿皮乙酸体外对白色念珠菌浮游菌和生物膜的作用。方法:10种中药为牡丹皮

黄连

丁香

肉桂

高良姜

桂枝

知母

苦参

蛇床子

白花蛇舌草

用水煎煮后浓缩

提取物用DMSO溶解

培养基稀释

体外微量稀释法检测药物对白色念珠菌浮游菌最低抑菌浓度（MIC）和抑制生物膜50%的浓度（SMIC50）的作用。结果:土槿皮乙酸对白色念珠菌的MIC为15.6 mg.L-1

对生物膜的SMIC50是31.2 mg.L-1。牡丹皮和高良姜对白色念珠菌生物膜有一定的抑制作用

SMIC50分别125

250 mg.L-1。黄连

丁香

肉桂

桂枝

知母

苦参

蛇床子

白花蛇舌草在2 000 mg.L-1均没有表现出抑菌活性。结论:体外微量稀释法检测到土槿皮乙酸对白色念珠菌浮游菌和生物膜具有明显的抑制作用

10种中药材中仅牡丹皮和高良姜的水煎液对白色念珠菌生物膜有一定的抑制作用

其他8种中药材的水煎液对白色念珠菌浮游菌和生物膜的抑制作用不明显。对中药抗真菌活性的评价值得进一步探讨。

Abstract

Objective:To observe the effect of ten traditional Chinese medicine and pseudolaric acid B（PB） on Candida albicans yeast and biofilm in vitro.Method:Moutan Cortex

Coptidis Rhizoma

Caryophylli Flos

Cinnamomi cortex

Alpiniae Officinarum Rhizoma

Cinnamomi Rhizoma Anemarrhenae Rhizoma

Sophore flavescentis Radir

Cnidii Fructus and Hedyotis diffusa Willd.were extracted with water

dissolved in DMSO.The microtiter method was used to test the antifungal effect against planktonic and biofilm C.albicans in vitro.Result: The MIC of PB inhibit the planktonic C.albicans was 15.6 mg·L-1

The MIC50 of PB inhibit the biofilm C.albicans was 31.2 mg·L-1.The MIC50 of Moutan Cortex and Alpiniae Officinarum Rhizoma inhibit the biofilm C.albicans was 125 mg·L-1 and 250 mg·L-1

respectively.The other medicines did not show any antifungal effect at 2 000 mg·L-1.Conclusion: PB showed some antifungal effect against planktonic and biofilm C.albicans

all the other traditional Chinese medicine water preparations did not show much activity against planktonic and biofilm C.albicans.The water extracts of traditional Chinese medicine did not showed much antifungal activity against the planktonic and biofilm C.albicans.The evaluation of the antifungal activity of traditional Chinese medicine need to be further discussed.

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Related Author

GONG Yu-jing

LIU Hong

FENG Shu-yi

ZHOU Yan-hua

SUN Ming-jie

Yan SHI

Weifeng YANG

Wensheng QI

Related Institution

Beijing Aerospace General Hospital

Experimental Research Center，China Academy of Chinese Medical Sciences

Guang'anmen Hosptial， China Academy of Chinese Medical Sciences

Jilin Agricultural University

Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

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