Study on Interaction of Antitussive Action on Mangiferin and Quercetin/Gallic Acid

LI Xue-jian1; DU Zheng-cai2; HU Wen-ji2; DENG Jia-gang2

doi:10.13422/j.cnki.syfjx.2011.23.063

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Study on Interaction of Antitussive Action on Mangiferin and Quercetin/Gallic Acid

更新时间：2024-09-23

- Study on Interaction of Antitussive Action on Mangiferin and Quercetin/Gallic Acid
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 17, Issue 23, Pages: 145-147(2011)
- 作者机构：
  
  1. 广西医科大学药学院
  2. 广西中医学院新药研究开发中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.23.063
  CLC： R285.5
- Published：2011
- 稿件说明：
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[1]李学坚,杜正彩,胡文姬,邓家刚.采用析因设计方法研究槲皮素和没食子酸对芒果苷镇咳作用的影响[J].中国实验方剂学杂志,2011,17(23):145-147.

LI Xue-jian1, DU Zheng-cai2, HU Wen-ji2, et al. Study on Interaction of Antitussive Action on Mangiferin and Quercetin/Gallic Acid[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 145-147.
[1]李学坚,杜正彩,胡文姬,邓家刚.采用析因设计方法研究槲皮素和没食子酸对芒果苷镇咳作用的影响[J].中国实验方剂学杂志,2011,17(23):145-147. DOI： 10.13422/j.cnki.syfjx.2011.23.063.

LI Xue-jian1, DU Zheng-cai2, HU Wen-ji2, et al. Study on Interaction of Antitussive Action on Mangiferin and Quercetin/Gallic Acid[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 145-147. DOI： 10.13422/j.cnki.syfjx.2011.23.063.

摘要

目的:芒果苷、槲皮素和没食子酸都是芒果叶的主要成分

含量均超过2%。本研究探讨芒果苷分别与槲皮素、没食子酸合用时

在镇咳作用上是否存在交互影响。方法:小鼠40只

雌雄各半

随机分为生理盐水组

生理盐水+芒果苷组（0.1 g.kg-1）

生理盐水+槲皮素组（0.1 g.kg-1）

生理盐水+芒果苷+槲皮素组（0.1+0.1 g.kg-1）

每组10只

采用浓氨水致咳的小鼠模型研究镇咳作用

记录小鼠3 min内的咳嗽次数。采用析因方差分析判断药物间是否存在交互影响。结果:与生理盐水组比较

芒果苷组有镇咳作用（P<0.05）

槲皮素组和没食子酸组则无（P>0.05）。芒果苷+槲皮素组的镇咳作用明显强于芒果苷组（P<0.01）;芒果苷+没食子酸组的镇咳作用与芒果苷组相当（P>0.05）。结论:芒果苷和槲皮素合用

有协同镇咳作用

能明显提高芒果苷的镇咳药效。芒果苷与没食子酸之间没有交互影响

两者合用

只表现出芒果苷的镇咳药效。

Abstract

Objective:Mangiferin

quercetin and gallic acid are the main chemical compositions of mango leaves with a content of more than 2% each.This article is to investigate the interaction effects of mangiferin and quercetin/gallic acid when they were used together for antitussive purpose.Method:Ammonia-induced cough model was employed to study antitussive effect.Factorial analysis of variance was employed to study interaction effects.Result:Compared with the ’mangiferin group’

the antitussive effect of ’mangiferin+quercetin group’ was stronger（P<0.01）

while the effect of ’mangiferin+ gallic acid group’ was equal（P>0.05）.Conclusion:There exists interaction between mangiferin and quercetin;quercetin can significantly improve mangiferin’s antitussive effect.No interaction effect between mangiferin and gallic acid;gallic acid indicates no antitussive effect when it is taken orally together with mangiferin.

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LI Xue-jian

DU Zheng-cai

HU Wen-ji

DENG Jia-gang

LI Yan-fang1

XIA Quan2

XU Feng-qing1

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Related Institution

College of Pharmacy,Dalian Medical University

Department of Pharmacy,First Affiliated Hospital of Dalian Medical University

Liaoning University of Traditional Chinese Medicine

School of Life Sciences，Beijing University of Chinese Medicine

The First Clinical Medical College，Nanjing University of Chinese Medicine

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